Platelet microbicidal activity is an important defense factor against viridans streptococcal endocarditis

J. Dankert; J. Krijgsveld; J. van der Werff; W. Joldersma; S.A.J. Zaat

doi:https://doi.org/10.1086/322802

Platelet microbicidal activity is an important defense factor against viridans streptococcal endocarditis

J. Dankert, J. Krijgsveld, J. van der Werff, W. Joldersma, S.A.J. Zaat

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Research output: Contribution to journal › Article › Academic › peer-review

45 Citations (Scopus)

Abstract

To study the role of platelet microbicidal activity in host defense against infective endocarditis (IE) due to viridans streptococci (VS), the susceptibility to platelet releasate of blood and oral VS isolates from patients with and without IE was compared. The influence of neutralization of platelet microbicidal activity was studied in 2 experimental IE models. Resistance to platelet releasate was more prevalent among VS from blood of patients with IE than from blood of bacteremic patients without IE and among oral VS isolates. Serum from rabbits vaccinated with human platelet sonicate supernatants neutralized human and rabbit platelet-released microbicidal activity and had antibodies recognizing microbicidal proteins thrombocidin-1 and -2 and other human platelet proteins. In the 2 rabbit IE models, vaccination increased the susceptibility to experimental IE due to platelet releasate-susceptible VS. Thus, platelet-released microbicidal activity is an important host defense factor against IE due to VS

Original language	Undefined/Unknown
Pages (from-to)	597-605
Journal	The Journal of Infectious Diseases
Volume	184
Issue number	5
DOIs	https://doi.org/10.1086/322802
Publication status	Published - 2001

Keywords

AMC wi-eigen

Access to Document

https://doi.org/10.1086/322802

https://pure.uva.nl/ws/files/3723465/17657_97751y.pdf

Cite this

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title = "Platelet microbicidal activity is an important defense factor against viridans streptococcal endocarditis",

abstract = "To study the role of platelet microbicidal activity in host defense against infective endocarditis (IE) due to viridans streptococci (VS), the susceptibility to platelet releasate of blood and oral VS isolates from patients with and without IE was compared. The influence of neutralization of platelet microbicidal activity was studied in 2 experimental IE models. Resistance to platelet releasate was more prevalent among VS from blood of patients with IE than from blood of bacteremic patients without IE and among oral VS isolates. Serum from rabbits vaccinated with human platelet sonicate supernatants neutralized human and rabbit platelet-released microbicidal activity and had antibodies recognizing microbicidal proteins thrombocidin-1 and -2 and other human platelet proteins. In the 2 rabbit IE models, vaccination increased the susceptibility to experimental IE due to platelet releasate-susceptible VS. Thus, platelet-released microbicidal activity is an important host defense factor against IE due to VS",

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T1 - Platelet microbicidal activity is an important defense factor against viridans streptococcal endocarditis

AU - Dankert, J.

AU - Krijgsveld, J.

AU - van der Werff, J.

AU - Joldersma, W.

AU - Zaat, S.A.J.

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Y1 - 2001

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AB - To study the role of platelet microbicidal activity in host defense against infective endocarditis (IE) due to viridans streptococci (VS), the susceptibility to platelet releasate of blood and oral VS isolates from patients with and without IE was compared. The influence of neutralization of platelet microbicidal activity was studied in 2 experimental IE models. Resistance to platelet releasate was more prevalent among VS from blood of patients with IE than from blood of bacteremic patients without IE and among oral VS isolates. Serum from rabbits vaccinated with human platelet sonicate supernatants neutralized human and rabbit platelet-released microbicidal activity and had antibodies recognizing microbicidal proteins thrombocidin-1 and -2 and other human platelet proteins. In the 2 rabbit IE models, vaccination increased the susceptibility to experimental IE due to platelet releasate-susceptible VS. Thus, platelet-released microbicidal activity is an important host defense factor against IE due to VS

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