Platelets as messengers of early-stage cancer

Siamack Sabrkhany, Marijke J. E. Kuijpers, Mirjam G. A. oude Egbrink, Arjan W. Griffioen

Research output: Contribution to journalReview articleAcademicpeer-review

21 Citations (Scopus)


Platelets have an important role in tumor angiogenesis, growth, and metastasis. The reciprocal interaction between cancer and platelets results in changes of several platelet characteristics. It is becoming clear that analysis of these platelet features could offer a new strategy in the search for biomarkers of cancer. Here, we review the human studies in which platelet characteristics (e.g., count, volume, protein, and mRNA content) are investigated in early-stage cancer. The main focus of this paper is to evaluate which platelet features are suitable for the development of a blood test that could detect cancer in its early stages.
Original languageEnglish
Pages (from-to)563-573
Number of pages11
JournalCancer and Metastasis Reviews
Issue number2
Early online date2021
Publication statusPublished - Jun 2021


  • Biomarker
  • Cancer
  • Early-stage
  • Platelets

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