Pneumococcal population in the era of vaccination: changes in composition and the relation to clinical outcomes

Karin E. Elberse; Gertjan H. J. Wagenvoort; Gerlinde N. Pluister; Hester E. de Melker; Elisabeth A. M. Sanders; Arie van der Ende; Mirjam J. Knol

doi:https://doi.org/10.2217/fmb.15.119

Pneumococcal population in the era of vaccination: changes in composition and the relation to clinical outcomes

Karin E. Elberse, Gertjan H. J. Wagenvoort, Gerlinde N. Pluister, Hester E. de Melker, Elisabeth A. M. Sanders, Arie van der Ende, Mirjam J. Knol

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Background: Vaccination of infants with pneumococcal conjugate vaccines (PCV) has resulted in major shifts in circulating serotypes. Aim: To investigate the impact of PCV7 on the clonal composition of the pneumococcal population, and the relation of clonal lineages and clinical outcome. Materials & methods: By using multiple-locus variable number of tandem repeat analysis, we assessed the pneumococcal populations before (n = 1154), 2-3 years after (n = 1190) and 4-6 years after (n = 1244) the introduction of PCV7 in The Netherlands. Results: We found statistically significant shifts in clonal lineages within serotypes 1 and 12F based on multiple-locus variable number of tandem repeat analysis results after the implementation of PCV7. Within serotype 12F, the increasing clonal lineage was significantly more associated with pneumonia. Conclusion: Shifts in clonal lineages within serotypes could impact the outcomes of pneumococcal disease and fill the niche of the vaccine serotypes

Original language	English
Pages (from-to)	31-41
Journal	Future microbiology
Volume	11
Issue number	1
DOIs	https://doi.org/10.2217/fmb.15.119
Publication status	Published - 2016

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https://doi.org/10.2217/fmb.15.119

Cite this

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title = "Pneumococcal population in the era of vaccination: changes in composition and the relation to clinical outcomes",

abstract = "Background: Vaccination of infants with pneumococcal conjugate vaccines (PCV) has resulted in major shifts in circulating serotypes. Aim: To investigate the impact of PCV7 on the clonal composition of the pneumococcal population, and the relation of clonal lineages and clinical outcome. Materials & methods: By using multiple-locus variable number of tandem repeat analysis, we assessed the pneumococcal populations before (n = 1154), 2-3 years after (n = 1190) and 4-6 years after (n = 1244) the introduction of PCV7 in The Netherlands. Results: We found statistically significant shifts in clonal lineages within serotypes 1 and 12F based on multiple-locus variable number of tandem repeat analysis results after the implementation of PCV7. Within serotype 12F, the increasing clonal lineage was significantly more associated with pneumonia. Conclusion: Shifts in clonal lineages within serotypes could impact the outcomes of pneumococcal disease and fill the niche of the vaccine serotypes",

author = "Elberse, {Karin E.} and Wagenvoort, {Gertjan H. J.} and Pluister, {Gerlinde N.} and {de Melker}, {Hester E.} and Sanders, {Elisabeth A. M.} and {van der Ende}, Arie and Knol, {Mirjam J.}",

year = "2016",

doi = "https://doi.org/10.2217/fmb.15.119",

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journal = "Future microbiology",

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T1 - Pneumococcal population in the era of vaccination: changes in composition and the relation to clinical outcomes

AU - Elberse, Karin E.

AU - Wagenvoort, Gertjan H. J.

AU - Pluister, Gerlinde N.

AU - de Melker, Hester E.

AU - Sanders, Elisabeth A. M.

AU - van der Ende, Arie

AU - Knol, Mirjam J.

PY - 2016

Y1 - 2016

N2 - Background: Vaccination of infants with pneumococcal conjugate vaccines (PCV) has resulted in major shifts in circulating serotypes. Aim: To investigate the impact of PCV7 on the clonal composition of the pneumococcal population, and the relation of clonal lineages and clinical outcome. Materials & methods: By using multiple-locus variable number of tandem repeat analysis, we assessed the pneumococcal populations before (n = 1154), 2-3 years after (n = 1190) and 4-6 years after (n = 1244) the introduction of PCV7 in The Netherlands. Results: We found statistically significant shifts in clonal lineages within serotypes 1 and 12F based on multiple-locus variable number of tandem repeat analysis results after the implementation of PCV7. Within serotype 12F, the increasing clonal lineage was significantly more associated with pneumonia. Conclusion: Shifts in clonal lineages within serotypes could impact the outcomes of pneumococcal disease and fill the niche of the vaccine serotypes

AB - Background: Vaccination of infants with pneumococcal conjugate vaccines (PCV) has resulted in major shifts in circulating serotypes. Aim: To investigate the impact of PCV7 on the clonal composition of the pneumococcal population, and the relation of clonal lineages and clinical outcome. Materials & methods: By using multiple-locus variable number of tandem repeat analysis, we assessed the pneumococcal populations before (n = 1154), 2-3 years after (n = 1190) and 4-6 years after (n = 1244) the introduction of PCV7 in The Netherlands. Results: We found statistically significant shifts in clonal lineages within serotypes 1 and 12F based on multiple-locus variable number of tandem repeat analysis results after the implementation of PCV7. Within serotype 12F, the increasing clonal lineage was significantly more associated with pneumonia. Conclusion: Shifts in clonal lineages within serotypes could impact the outcomes of pneumococcal disease and fill the niche of the vaccine serotypes

U2 - https://doi.org/10.2217/fmb.15.119

DO - https://doi.org/10.2217/fmb.15.119

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SN - 1746-0913

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JO - Future microbiology

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