TY - JOUR
T1 - Polygenic differential susceptibility to prenatal adversity
AU - Belsky, Jay
AU - Pokhvisneva, Irina
AU - Rema, Anu Sathyan Sathyapalan
AU - Broekman, Birit F P
AU - Pluess, Michael
AU - O'Donnell, Kieran J
AU - Meaney, Michael J
AU - Silveira, Patrícia P
PY - 2019
Y1 - 2019
N2 - A recent article in this journal reported a number of gene × environment interactions involving a serotonin transporter-gene network polygenic score and a composite index of prenatal adversity predicting several problem behavior outcomes at 48 months (e.g., anxious/depressed, pervasive developmental problems) and at 60 months (e.g., withdrawal, internalizing problems), yet did not illuminate the nature or form these genetic × environment interactions took. Here we report results of six additional analyses to evaluate whether these interactions reflected diathesis-stress or differential-susceptibility related processes. Analyses of the regions of significance and proportion of interaction index are consistent with the diathesis-stress model, seemingly because of the truncated nature of the adversity score (which did not extend to supportive/positive prenatal experiences/exposures); in contrast, the proportion (of cases) affected index favors the differential-susceptibility model. These results suggest the need for future studies to extend measurement of the prenatal environment to highly supportive experiences and exposures.
AB - A recent article in this journal reported a number of gene × environment interactions involving a serotonin transporter-gene network polygenic score and a composite index of prenatal adversity predicting several problem behavior outcomes at 48 months (e.g., anxious/depressed, pervasive developmental problems) and at 60 months (e.g., withdrawal, internalizing problems), yet did not illuminate the nature or form these genetic × environment interactions took. Here we report results of six additional analyses to evaluate whether these interactions reflected diathesis-stress or differential-susceptibility related processes. Analyses of the regions of significance and proportion of interaction index are consistent with the diathesis-stress model, seemingly because of the truncated nature of the adversity score (which did not extend to supportive/positive prenatal experiences/exposures); in contrast, the proportion (of cases) affected index favors the differential-susceptibility model. These results suggest the need for future studies to extend measurement of the prenatal environment to highly supportive experiences and exposures.
U2 - https://doi.org/10.1017/S0954579418000378
DO - https://doi.org/10.1017/S0954579418000378
M3 - Article
C2 - 30081968
SN - 0954-5794
VL - 39
SP - 439
EP - 441
JO - Development and psychopathology
JF - Development and psychopathology
ER -