TY - JOUR
T1 - Polygenic risk of obesity and BMI trajectories over 36 years
T2 - A longitudinal study of adult Finnish twins
AU - Berntzen, Bram J.
AU - Palviainen, Teemu
AU - Silventoinen, Karri
AU - Pietiläinen, Kirsi H.
AU - Kaprio, Jaakko
N1 - Funding Information: The study was supported by the Academy of Finland (Jaakko Kaprio: 263278, 264146, 265240, 308248, 312073, 336823, 352792; Kirsi H. Pietiläinen: 272376, 266286, 314383, 335443), the Wellcome Trust Sanger Institute (Jaakko Kaprio), the Broad Institute (Jaakko Kaprio), ENGAGE—European Network for Genetic and Genomic Epidemiology (Jaakko Kaprio: FP7‐HEALTH‐F4‐2007, 201413), Finnish Medical Foundation (Kirsi H. Pietiläinen), Finnish Diabetes Research Foundation (Kirsi H. Pietiläinen), Novo Nordisk Foundation (Kirsi H. Pietiläinen: NNF10OC1013354, NNF17OC0027232, and NNF20OC0060547), Gyllenberg Foundation (Kirsi H. Pietiläinen), Sigrid Juselius Foundation (Jaakko Kaprio and Kirsi H. Pietiläinen), Helsinki University Hospital Research Funds (Kirsi H. Pietiläinen), Jalmari and Rauha Ahokas Foundation (Kirsi H. Pietiläinen), Finnish Foundation for Cardiovascular Research (Kirsi H. Pietiläinen), Government Research Funds (Kirsi H. Pietiläinen), Helsinki University Hospital (Kirsi H. Pietiläinen), and the University of Helsinki (Kirsi H. Pietiläinen). Publisher Copyright: © 2023 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Objective: This study investigated 36-year BMI trajectories in twins whose BMI in young adulthood was below, within, or above their genetically predicted BMI, with a focus on twin pairs with large intrapair BMI differences (within-pair ΔBMI ≥ 3 kg/m2). Methods: Together, 3227 like-sexed twin pairs (34% monozygotic) were examined at age ~30 years in 1975 and followed up in 1981, 1990, and 2011. An individual's observed BMI in 1975 was considered within (±2.0), below (<−2.0), or above (>+2.0) genetically predicted BMI, measured by a polygenic risk score of 996,919 single nucleotide polymorphisms. Results: In monozygotic and dizygotic twin pairs with large intrapair BMI differences, the co-twin with a higher observed BMI in 1975 deviated above predicted BMI more frequently (~2/3) than the co-twin with a lower BMI deviated below prediction (~1/3). Individuals below, within, and above prediction in 1975 reached, respectively, normal weight, overweight, and obesity by 2011, with a mean BMI increase of 4.5 (95% CI: 4.3–4.8). Conclusions: Categorizing BMI as below, within, or above polygenic risk score-predicted BMI helps identifying individuals who have been resistant or susceptible to weight gain. This may provide new insights into determinants and consequences of obesity.
AB - Objective: This study investigated 36-year BMI trajectories in twins whose BMI in young adulthood was below, within, or above their genetically predicted BMI, with a focus on twin pairs with large intrapair BMI differences (within-pair ΔBMI ≥ 3 kg/m2). Methods: Together, 3227 like-sexed twin pairs (34% monozygotic) were examined at age ~30 years in 1975 and followed up in 1981, 1990, and 2011. An individual's observed BMI in 1975 was considered within (±2.0), below (<−2.0), or above (>+2.0) genetically predicted BMI, measured by a polygenic risk score of 996,919 single nucleotide polymorphisms. Results: In monozygotic and dizygotic twin pairs with large intrapair BMI differences, the co-twin with a higher observed BMI in 1975 deviated above predicted BMI more frequently (~2/3) than the co-twin with a lower BMI deviated below prediction (~1/3). Individuals below, within, and above prediction in 1975 reached, respectively, normal weight, overweight, and obesity by 2011, with a mean BMI increase of 4.5 (95% CI: 4.3–4.8). Conclusions: Categorizing BMI as below, within, or above polygenic risk score-predicted BMI helps identifying individuals who have been resistant or susceptible to weight gain. This may provide new insights into determinants and consequences of obesity.
UR - http://www.scopus.com/inward/record.url?scp=85177548894&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/oby.23906
DO - https://doi.org/10.1002/oby.23906
M3 - Article
C2 - 37987187
SN - 1930-7381
VL - 31
SP - 3086
EP - 3094
JO - Obesity
JF - Obesity
IS - 12
ER -