Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Robert A. Power; Stacy Steinberg; Gyda Bjornsdottir; Cornelius A. Rietveld; Abdel Abdellaoui; Michel M. Nivard; Magnus Johannesson; Tessel E. Galesloot; Jouke J. Hottenga; Gonneke Willemsen; David Cesarini; Daniel J. Benjamin; Patrik K.E. Magnusson; Fredrik Ullén; Henning Tiemeier; Albert Hofman; Frank J.A. Van Rooij; G. Bragi Walters; Engilbert Sigurdsson; Thorgeir E. Thorgeirsson; Andres Ingason; Agnar Helgason; Augustine Kong; Lambertus A. Kiemeney; Philipp Koellinger; Dorret I. Boomsma; Daniel Gudbjartsson; Hreinn Stefansson; Kari Stefansson

doi:https://doi.org/10.1038/nn.4040

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Robert A. Power, Stacy Steinberg, Gyda Bjornsdottir, Cornelius A. Rietveld, Abdel Abdellaoui, Michel M. Nivard, Magnus Johannesson, Tessel E. Galesloot, Jouke J. Hottenga, Gonneke Willemsen, David Cesarini, Daniel J. Benjamin, Patrik K.E. Magnusson, Fredrik Ullén, Henning Tiemeier, Albert Hofman, Frank J.A. Van Rooij, G. Bragi Walters, Engilbert Sigurdsson, Thorgeir E. ThorgeirssonAndres Ingason, Agnar Helgason, Augustine Kong, Lambertus A. Kiemeney, Philipp Koellinger, Dorret I. Boomsma, Daniel Gudbjartsson, Hreinn Stefansson, Kari Stefansson

Adult Psychiatry (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

262 Citations (Scopus)

Abstract

We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

Original language	English
Pages (from-to)	953-955
Number of pages	3
Journal	Nature neuroscience
Volume	18
Issue number	7
DOIs	https://doi.org/10.1038/nn.4040
Publication status	Published - 25 Jun 2015

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Power, R. A., Steinberg, S., Bjornsdottir, G., Rietveld, C. A., Abdellaoui, A., Nivard, M. M., Johannesson, M., Galesloot, T. E., Hottenga, J. J., Willemsen, G., Cesarini, D., Benjamin, D. J., Magnusson, P. K. E., Ullén, F., Tiemeier, H., Hofman, A., Van Rooij, F. J. A., Walters, G. B., Sigurdsson, E., ... Stefansson, K. (2015). Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. Nature neuroscience, 18(7), 953-955. https://doi.org/10.1038/nn.4040

@article{da425dc21f934b9a9c97e5378a559518,

title = "Polygenic risk scores for schizophrenia and bipolar disorder predict creativity",

abstract = "We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 {\^a} '6 and 3.8 × 10 {\^a} '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.",

author = "Power, {Robert A.} and Stacy Steinberg and Gyda Bjornsdottir and Rietveld, {Cornelius A.} and Abdel Abdellaoui and Nivard, {Michel M.} and Magnus Johannesson and Galesloot, {Tessel E.} and Hottenga, {Jouke J.} and Gonneke Willemsen and David Cesarini and Benjamin, {Daniel J.} and Magnusson, {Patrik K.E.} and Fredrik Ull{\'e}n and Henning Tiemeier and Albert Hofman and {Van Rooij}, {Frank J.A.} and Walters, {G. Bragi} and Engilbert Sigurdsson and Thorgeirsson, {Thorgeir E.} and Andres Ingason and Agnar Helgason and Augustine Kong and Kiemeney, {Lambertus A.} and Philipp Koellinger and Boomsma, {Dorret I.} and Daniel Gudbjartsson and Hreinn Stefansson and Kari Stefansson",

note = "Funding Information: The authors are grateful to the participants and thank the staff at the Kr{\'o}kh{\'a}ls recruitment center. We thank P. Arp, M. Jhamai, M. Moorhouse, M. Verkerk and S. Bervoets for their assistance in creating the GWAS database. The authors are very grateful to the participants and staff from the Rotterdam Study, participating general practitioners and the pharmacists. The Netherlands Twin Registry thanks all participants. The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement 115008, resources of which are composed of European Federation of Pharmaceutical Industries and Associations (EFPIA) in-kind contributions and financial contributions from the European Union{\textquoteright}s Seventh Framework Programme (FP7/2007-2013) and the European Union–funded FP7-People-2011-IAPP grant PsychDPC (GA 286213). This study presents independent research funded in part by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley, NHS Foundation Trust and King{\textquoteright}s College London. The views expressed are those of the authors and not necessarily those of the UK National Health Service, the NIHR or the Department of Health. The Rotterdam Study was funded by the Netherlands Organisation for Scientific Research NWO Investments (175.010.2005.011, 911-03-012), the Research Institute for Diseases in the Elderly (014-93-015; RIDE2) and the Netherlands Genomics Initiative (NGI)/Netherlands Consortium for Healthy Aging (NCHA) project 050-060-810. The Rotterdam Study is funded by the Erasmus Medical Center; Erasmus University, Rotterdam; the Netherlands Organization for the Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly (RIDE); the Ministry of Education, Culture, and Science; the Ministry for Health, Welfare, and Sports; the European Commission (DG XII); and the Municipality of Rotterdam. Funding for the Netherlands Twin Registry was obtained from the Netherlands Organization for Scientific Research (NWO) and MagW/ZonMW, BBMRI-NL (184.021.007), the VU University Institute for Health and Care Research (EMGO+) and Neuroscience Campus Amsterdam, the European Science Council (ERC) Genetics of Mental Illness (230374), Avera Institute for Human Genetics and US National Institute of Mental Health (1RC2MH089951-01 and 1RC2 MH089995). The Swedish Twin Registry was financially supported by the Ragnar S{\"o}derberg Foundation (E9/11), the Swedish Research Council (421-2013-1061), the Jan Wallander and Tom Hedelius Foundation (P2012-0002:1), the Sven and Dagmar Sal{\'e}n Foundation, the Bank of Sweden Tercentenary Foundation (M11-0451:1) and the Karolinska Institutet. Some of the statistical analyses were carried out on the Genetic Cluster Computer (http://www.geneticcluster.org/), which is financially supported by the Netherlands Scientific Organization (NWO 480-05-003 PI: Posthuma) along with a supplement from the Dutch Brain Foundation and the VU University Amsterdam. Publisher Copyright: {\textcopyright} 2015 Nature America, Inc.",

year = "2015",

month = jun,

day = "25",

doi = "https://doi.org/10.1038/nn.4040",

language = "English",

volume = "18",

pages = "953--955",

journal = "Nature neuroscience",

issn = "1097-6256",

publisher = "Nature Publishing Group",

number = "7",

}

Power, RA, Steinberg, S, Bjornsdottir, G, Rietveld, CA, Abdellaoui, A, Nivard, MM, Johannesson, M, Galesloot, TE, Hottenga, JJ, Willemsen, G, Cesarini, D, Benjamin, DJ, Magnusson, PKE, Ullén, F, Tiemeier, H, Hofman, A, Van Rooij, FJA, Walters, GB, Sigurdsson, E, Thorgeirsson, TE, Ingason, A, Helgason, A, Kong, A, Kiemeney, LA, Koellinger, P, Boomsma, DI, Gudbjartsson, D, Stefansson, H & Stefansson, K 2015, 'Polygenic risk scores for schizophrenia and bipolar disorder predict creativity', Nature neuroscience, vol. 18, no. 7, pp. 953-955. https://doi.org/10.1038/nn.4040

TY - JOUR

T1 - Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

AU - Power, Robert A.

AU - Steinberg, Stacy

AU - Bjornsdottir, Gyda

AU - Rietveld, Cornelius A.

AU - Abdellaoui, Abdel

AU - Nivard, Michel M.

AU - Johannesson, Magnus

AU - Galesloot, Tessel E.

AU - Hottenga, Jouke J.

AU - Willemsen, Gonneke

AU - Cesarini, David

AU - Benjamin, Daniel J.

AU - Magnusson, Patrik K.E.

AU - Ullén, Fredrik

AU - Tiemeier, Henning

AU - Hofman, Albert

AU - Van Rooij, Frank J.A.

AU - Walters, G. Bragi

AU - Sigurdsson, Engilbert

AU - Thorgeirsson, Thorgeir E.

AU - Ingason, Andres

AU - Helgason, Agnar

AU - Kong, Augustine

AU - Kiemeney, Lambertus A.

AU - Koellinger, Philipp

AU - Boomsma, Dorret I.

AU - Gudbjartsson, Daniel

AU - Stefansson, Hreinn

AU - Stefansson, Kari

N1 - Funding Information: The authors are grateful to the participants and thank the staff at the Krókháls recruitment center. We thank P. Arp, M. Jhamai, M. Moorhouse, M. Verkerk and S. Bervoets for their assistance in creating the GWAS database. The authors are very grateful to the participants and staff from the Rotterdam Study, participating general practitioners and the pharmacists. The Netherlands Twin Registry thanks all participants. The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement 115008, resources of which are composed of European Federation of Pharmaceutical Industries and Associations (EFPIA) in-kind contributions and financial contributions from the European Union’s Seventh Framework Programme (FP7/2007-2013) and the European Union–funded FP7-People-2011-IAPP grant PsychDPC (GA 286213). This study presents independent research funded in part by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley, NHS Foundation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the UK National Health Service, the NIHR or the Department of Health. The Rotterdam Study was funded by the Netherlands Organisation for Scientific Research NWO Investments (175.010.2005.011, 911-03-012), the Research Institute for Diseases in the Elderly (014-93-015; RIDE2) and the Netherlands Genomics Initiative (NGI)/Netherlands Consortium for Healthy Aging (NCHA) project 050-060-810. The Rotterdam Study is funded by the Erasmus Medical Center; Erasmus University, Rotterdam; the Netherlands Organization for the Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly (RIDE); the Ministry of Education, Culture, and Science; the Ministry for Health, Welfare, and Sports; the European Commission (DG XII); and the Municipality of Rotterdam. Funding for the Netherlands Twin Registry was obtained from the Netherlands Organization for Scientific Research (NWO) and MagW/ZonMW, BBMRI-NL (184.021.007), the VU University Institute for Health and Care Research (EMGO+) and Neuroscience Campus Amsterdam, the European Science Council (ERC) Genetics of Mental Illness (230374), Avera Institute for Human Genetics and US National Institute of Mental Health (1RC2MH089951-01 and 1RC2 MH089995). The Swedish Twin Registry was financially supported by the Ragnar Söderberg Foundation (E9/11), the Swedish Research Council (421-2013-1061), the Jan Wallander and Tom Hedelius Foundation (P2012-0002:1), the Sven and Dagmar Salén Foundation, the Bank of Sweden Tercentenary Foundation (M11-0451:1) and the Karolinska Institutet. Some of the statistical analyses were carried out on the Genetic Cluster Computer (http://www.geneticcluster.org/), which is financially supported by the Netherlands Scientific Organization (NWO 480-05-003 PI: Posthuma) along with a supplement from the Dutch Brain Foundation and the VU University Amsterdam. Publisher Copyright: © 2015 Nature America, Inc.

PY - 2015/6/25

Y1 - 2015/6/25

N2 - We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

AB - We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

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U2 - https://doi.org/10.1038/nn.4040

DO - https://doi.org/10.1038/nn.4040

M3 - Article

C2 - 26053403

SN - 1097-6256

VL - 18

SP - 953

EP - 955

JO - Nature neuroscience

JF - Nature neuroscience

IS - 7

ER -

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

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