Abstract
Original language | English |
---|---|
Pages (from-to) | 510-520 |
Journal | American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics |
Volume | 165 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Sept 2014 |
Externally published | Yes |
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In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 165, No. 6, 01.09.2014, p. 510-520.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children
AU - de Zeeuw, Eveline L.
AU - van Beijsterveldt, Catharina E. M.
AU - Glasner, Tina J.
AU - Bartels, M.
AU - Ehli, Erik A.
AU - Davies, Gareth E.
AU - Hudziak, James J.
AU - Rietveld, Cornelius A.
AU - Groen-Blokhuis, Maria M.
AU - Hottenga, Jouke Jan
AU - de Geus, Eco J. C.
AU - Boomsma, Dorret I.
AU - Abdellaoui, Abdel
AU - Agrawal, Arpana
AU - Albrecht, Eva
AU - Alizadeh, Behrooz Z.
AU - Allik, J. ri
AU - Amin, Najaf
AU - Attia, John R.
AU - Bandinelli, Stefania
AU - Barnard, John
AU - Bastardot, François
AU - Baumeister, Sebastian E.
AU - Beauchamp, Jonathan
AU - Benjamin, Daniel J.
AU - Benke, Kelly S.
AU - Bennett, David A.
AU - Berger, Klaus
AU - Bielak, Lawrence F.
AU - Bierut, Laura J.
AU - Boatman, Jeffrey A.
AU - Boyle, Patricia A.
AU - Bültmann, Ute
AU - Campbell, Harry
AU - Cesarini, David
AU - Chabris, Christopher F.
AU - Cherkas, Lynn
AU - Chung, Mina K.
AU - Conley, Dalton
AU - Cucca, Francesco
AU - Davey-Smith, George
AU - Davies, Gail
AU - Andrade, Mariza De
AU - de Jager, Philip L.
AU - Leeuw, Christiaan De
AU - de, Jan-Emmanuel
AU - Deary, Ian J.
AU - Dedoussis, George V.
AU - Deloukas, Panos
AU - Derringer, Jaime
AU - Dimitriou, Maria
AU - Eiriksdottir, Gudny
AU - Eklund, Niina
AU - Elderson, Martin F.
AU - Eriksson, Johan G.
AU - Toñu Esko, null
AU - Evans, Daniel S.
AU - Evans, David M.
AU - Faul, Jessica D.
AU - Fehrmann, Rudolf
AU - Ferrucci, Luigi
AU - Fischer, Krista
AU - Franke, Lude
AU - Garcia, Melissa E.
AU - Gieger, Christian
AU - Gjessing, Hakon K.
AU - Groenen, Patrick J. F.
AU - Grönberg, Henrik
AU - Gudnason, Vilmundur
AU - Hägg, Sara
AU - Hall, Per
AU - Harris, Jennifer R.
AU - Harris, Juliette M.
AU - Harris, Tamara B.
AU - Hastie, Nicholas D.
AU - Hayward, Caroline
AU - Heath, Andrew C.
AU - Hernandez, Dena G.
AU - Hoffmann, Wolgang
AU - Hofman, Adriaan
AU - Hofman, Albert
AU - Holle, Rolf
AU - Holliday, Elizabeth G.
AU - Holzapfel, Christina
AU - Hottenga, Jouke-Jan
AU - Iacono, William G.
AU - Ibrahim-Verbaas, Carla A.
AU - Illig, Thomas
AU - Ingelsson, Erik
AU - Jacobsson, Bo
AU - Järvelin, Marjo-Riitta
AU - Jhun, Min A.
AU - Johannesson, Magnus
AU - Joshi, Peter K.
AU - Jugessur, Astanand
AU - Kaakinen, Marika
AU - Kähönen, Mika
AU - Kanoni, Stavroula
AU - Kaprio, Jaakkko
AU - Kardia, Sharon L. R.
AU - Karjalainen, Juha
AU - Kirkpatrick, Robert M.
AU - Koellinger, Philipp D.
AU - Kolcic, Ivana
AU - Kowgier, Matthew
AU - Kristiansson, Kati
AU - Krueger, RobertF.
AU - Ltan Kutalik, Z.
AU - Lahti, Jari
AU - Laibson, David
AU - Latvala, Antti
AU - Launer, Lenore J.
AU - Lawlor, Debbie A.
AU - Lee, Sang H.
AU - Lethimäki, Terho
AU - Li, Jingmei
AU - Lichtenstein, Paul
AU - Lichtner, Peter K.
AU - Liewald, David C.
AU - Lin, Peng
AU - Lind, Penelope A.
AU - Liu, Yongmei
AU - Lohman, Kurt
AU - Loitfelder, Marisa
AU - Madden, Pamela A.
AU - Magnusson, Patrick K. E.
AU - Mäkinen, Tomi E.
AU - Vidal, Pedro Marques
AU - Martin, Nicolas W.
AU - Martin, Nicholas G.
AU - Masala, Marco
AU - McGue, Matt
AU - McMahon, George
AU - Medland, Sarah E.
AU - Meirelles, Osorio
AU - Metspalu, Andres
AU - Meyer, Michelle N.
AU - Mielck, Andreas
AU - Milani, Lili
AU - Miller, Michael B.
AU - Montgomery, Grant W.
AU - Mukherjee, Sutapa
AU - Myhre, Ronny
AU - Nuotio, Marja-Liisa
AU - Nyholt, Dale R.
AU - Oldmeadow, Christopher J.
AU - Oostra, Ben A.
AU - Palmer, Lyle J.
AU - Palotie, Aarno
AU - Penninx, Brenda
AU - Perola, Markus
AU - Petrovic, Katja E.
AU - Peyrot, Wouter J.
AU - Peyser, Patricia A.
AU - Ozren Polasek, null
AU - Posthuma, Danielle
AU - Preisig, Martin
AU - Quaye, Lydia
AU - Räikkönen, Katri
AU - Raitakari, Olli T.
AU - Realo, Anu
AU - Reinmaa, Eva
AU - Rice, John P.
AU - Ring, Susan M.
AU - Ripatti, Samuli
AU - Rivadeneira, Fernando
AU - Rizzi, Thais S.
AU - Rudan, Igor
AU - Rustichini, Aldo
AU - Salomaa, Veikko
AU - Sarin, Antti-Pekka
AU - Schlessinger, David
AU - Schmidt, Helena
AU - Schmidt, Reinhold
AU - Scott, Rodney J.
AU - Shakhbazov, Konstantin
AU - Smith, Albert V.
AU - Smith, Jennifer A.
AU - Snieder, Harold
AU - Pourcain, Beate St
AU - Starr, John M.
AU - Sul, Jae Hoon
AU - Surakka, Ida
AU - Svento, Rauli
AU - Tanaka, Toshiko
AU - Terracciano, Antonio
AU - Teumer, Alexander
AU - Thurik, A. Roy
AU - Tiemeier, Henning
AU - Timpson, Nicholas J.
AU - Uitterlinden, André G.
AU - van der Loos, Matthijs J. H. M.
AU - van Duijn, Cornelia M.
AU - van Rooij, Frank J. A.
AU - van Wagoner, David R.
AU - Vartiainen, Erkki
AU - Viikari, Jorma
AU - Visscher, Peter M.
AU - Vitart, Veronique
AU - Vollenweider, Peter K.
AU - Völzke, Henry
AU - Vonk, Judith M.
AU - Waeber, G. rard
AU - Weir, David R.
AU - Wellmann, J. rgen
AU - Westra, Harm-Jan
AU - Wichmann, H. -Erich
AU - Widen, Elisabeth
AU - Willemsen, Gonneke
AU - Wilson, James F.
AU - Wright, Alan F.
AU - Yang, Jian
AU - Yu, Lei
AU - Zhao, Wei
PY - 2014/9/1
Y1 - 2014/9/1
N2 - The American Psychiatric Association estimates that 3 to 7 per cent of all school aged children are diagnosed with attention deficit hyperactivity disorder (ADHD). Even after correcting for general cognitive ability, numerous studies report a negative association between ADHD and educational achievement. With polygenic scores we examined whether genetic variants that have a positive influence on educational attainment have a protective effect against ADHD. The effect sizes from a large GWA meta-analysis of educational attainment in adults were used to calculate polygenic scores in an independent sample of 12-year-old children from the Netherlands Twin Register. Linear mixed models showed that the polygenic scores significantly predicted educational achievement, school performance, ADHD symptoms and attention problems in children. These results confirm the genetic overlap between ADHD and educational achievement, indicating that one way to gain insight into genetic variants responsible for variation in ADHD is to include data on educational achievement, which are available at a larger scale. © 2014 Wiley Periodicals, Inc.
AB - The American Psychiatric Association estimates that 3 to 7 per cent of all school aged children are diagnosed with attention deficit hyperactivity disorder (ADHD). Even after correcting for general cognitive ability, numerous studies report a negative association between ADHD and educational achievement. With polygenic scores we examined whether genetic variants that have a positive influence on educational attainment have a protective effect against ADHD. The effect sizes from a large GWA meta-analysis of educational attainment in adults were used to calculate polygenic scores in an independent sample of 12-year-old children from the Netherlands Twin Register. Linear mixed models showed that the polygenic scores significantly predicted educational achievement, school performance, ADHD symptoms and attention problems in children. These results confirm the genetic overlap between ADHD and educational achievement, indicating that one way to gain insight into genetic variants responsible for variation in ADHD is to include data on educational achievement, which are available at a larger scale. © 2014 Wiley Periodicals, Inc.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84906101359&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/25044548
U2 - https://doi.org/10.1002/ajmg.b.32254
DO - https://doi.org/10.1002/ajmg.b.32254
M3 - Article
C2 - 25044548
SN - 1552-4841
VL - 165
SP - 510
EP - 520
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
IS - 6
ER -