TY - JOUR
T1 - Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease
AU - Keliher, Edmund J.
AU - Ye, Yu-Xiang
AU - Wojtkiewicz, Gregory R.
AU - Aguirre, Aaron D.
AU - Tricot, Benoit
AU - Senders, Max L.
AU - Groenen, Hannah
AU - Fay, Francois
AU - Perez-Medina, Carlos
AU - Calcagno, Claudia
AU - Carlucci, Giuseppe
AU - Reiner, Thomas
AU - Sun, Yuan
AU - Courties, Gabriel
AU - Iwamoto, Yoshiko
AU - Kim, Hye-Yeong
AU - Wang, Cuihua
AU - Chen, John W.
AU - Swirski, Filip K.
AU - Wey, Hsiao-Ying
AU - Hooker, Jacob
AU - Fayad, Zahi A.
AU - Mulder, Willem J. M.
AU - Weissleder, Ralph
AU - Nahrendorf, Matthias
PY - 2017
Y1 - 2017
N2 - Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring macrophages in patients. Here we describe positron emission tomography (PET) imaging with F-18-Macroflor, a modified polyglucose nanoparticle with high avidity for macrophages. Due to its small size, Macroflor is excreted renally, a prerequisite for imaging with the isotope flourine-18. The particle's short blood half-life, measured in three species, including a primate, enables macrophage imaging in inflamed cardiovascular tissues. Macroflor enriches in cardiac and plaque macrophages, thereby increasing PET signal in murine infarcts and both mouse and rabbit atherosclerotic plaques. In PET/magnetic resonance imaging (MRI) experiments, Macroflor PET imaging detects changes in macrophage population size while molecular MRI reports on increasing or resolving inflammation. These data suggest that Macroflor PET/MRI could be a clinical tool to non-invasively monitor macrophage biology
AB - Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring macrophages in patients. Here we describe positron emission tomography (PET) imaging with F-18-Macroflor, a modified polyglucose nanoparticle with high avidity for macrophages. Due to its small size, Macroflor is excreted renally, a prerequisite for imaging with the isotope flourine-18. The particle's short blood half-life, measured in three species, including a primate, enables macrophage imaging in inflamed cardiovascular tissues. Macroflor enriches in cardiac and plaque macrophages, thereby increasing PET signal in murine infarcts and both mouse and rabbit atherosclerotic plaques. In PET/magnetic resonance imaging (MRI) experiments, Macroflor PET imaging detects changes in macrophage population size while molecular MRI reports on increasing or resolving inflammation. These data suggest that Macroflor PET/MRI could be a clinical tool to non-invasively monitor macrophage biology
M3 - Article
C2 - 28091604
SN - 2041-1723
VL - 8
JO - Nature communications
JF - Nature communications
M1 - 14064
ER -