Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer

Lambertus A. Kiemeney; Kjeld P. van Houwelingen; Manon Bogaerts; J. Alfred Witjes; Dorine W. Swinkels; Martin den Heijer; Barbara Franke; Jack A. Schalken; Gerald W. Verhaegh

doi:https://doi.org/10.1016/j.ejca.2006.05.033

Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer

Lambertus A. Kiemeney, Kjeld P. van Houwelingen, Manon Bogaerts, J. Alfred Witjes, Dorine W. Swinkels, Martin den Heijer, Barbara Franke, Jack A. Schalken, Gerald W. Verhaegh

Internal Medicine (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

Abstract

Aim: E-cadherin plays a role in carcinogenesis. For two genetic polymorphisms in the gene (CDH1) promoter, a reduced transcription has been reported: a C/A single nucleotide polymorphism (SNP) and a G/GA SNP at -160 bp and -347 bp, respectively, upstream of the transcriptional start site. We studied the association between both polymorphisms and the risk of bladder cancer. Methods: One hundred and ninety-seven patients with bladder cancer and 344 population controls were genotyped and haplotyped for both SNPs. Results: A borderline significantly increased risk for bladder cancer was found for A allele carriers (OR 1.36; 95% CI: 0.96-1.94). We did not find any association between the -347 G/GA SNP and bladder cancer. Haplotype analyses did not yield much stronger associations with bladder cancer than the -160 C/A genotype analyses. Conclusion: This study supports earlier suggestions that the -160 C/A SNP in the CDH1 promoter is a risk factor for bladder cancer.

Original language	English
Pages (from-to)	3219-3227
Number of pages	9
Journal	European Journal of Cancer
Volume	42
Issue number	18
DOIs	https://doi.org/10.1016/j.ejca.2006.05.033
Publication status	Published - Dec 2006

Keywords

Bladder cancer
E-cadherin promoter
Single nucleotide polymorphisms

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@article{d43ee60d923744d29eecf907ba4fef24,

title = "Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer",

abstract = "Aim: E-cadherin plays a role in carcinogenesis. For two genetic polymorphisms in the gene (CDH1) promoter, a reduced transcription has been reported: a C/A single nucleotide polymorphism (SNP) and a G/GA SNP at -160 bp and -347 bp, respectively, upstream of the transcriptional start site. We studied the association between both polymorphisms and the risk of bladder cancer. Methods: One hundred and ninety-seven patients with bladder cancer and 344 population controls were genotyped and haplotyped for both SNPs. Results: A borderline significantly increased risk for bladder cancer was found for A allele carriers (OR 1.36; 95% CI: 0.96-1.94). We did not find any association between the -347 G/GA SNP and bladder cancer. Haplotype analyses did not yield much stronger associations with bladder cancer than the -160 C/A genotype analyses. Conclusion: This study supports earlier suggestions that the -160 C/A SNP in the CDH1 promoter is a risk factor for bladder cancer.",

keywords = "Bladder cancer, E-cadherin promoter, Single nucleotide polymorphisms",

author = "Kiemeney, {Lambertus A.} and {van Houwelingen}, {Kjeld P.} and Manon Bogaerts and Witjes, {J. Alfred} and Swinkels, {Dorine W.} and Heijer, {Martin den} and Barbara Franke and Schalken, {Jack A.} and Verhaegh, {Gerald W.}",

note = "Funding Information: We would like to thank Mr. Melvin Siliakus, Ms. Lisa Basten, Mr. Siem Klaver and Mr. Erwin Wiegerinck for their excellent technical assistance. This work was supported by the Sacha Swarttouw-Hijmans Foundation and the Netherlands Cancer Society (Grant KUN1996-1339).",

year = "2006",

month = dec,

doi = "https://doi.org/10.1016/j.ejca.2006.05.033",

language = "English",

volume = "42",

pages = "3219--3227",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Limited",

number = "18",

}

TY - JOUR

T1 - Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer

AU - Kiemeney, Lambertus A.

AU - van Houwelingen, Kjeld P.

AU - Bogaerts, Manon

AU - Witjes, J. Alfred

AU - Swinkels, Dorine W.

AU - Heijer, Martin den

AU - Franke, Barbara

AU - Schalken, Jack A.

AU - Verhaegh, Gerald W.

N1 - Funding Information: We would like to thank Mr. Melvin Siliakus, Ms. Lisa Basten, Mr. Siem Klaver and Mr. Erwin Wiegerinck for their excellent technical assistance. This work was supported by the Sacha Swarttouw-Hijmans Foundation and the Netherlands Cancer Society (Grant KUN1996-1339).

PY - 2006/12

Y1 - 2006/12

N2 - Aim: E-cadherin plays a role in carcinogenesis. For two genetic polymorphisms in the gene (CDH1) promoter, a reduced transcription has been reported: a C/A single nucleotide polymorphism (SNP) and a G/GA SNP at -160 bp and -347 bp, respectively, upstream of the transcriptional start site. We studied the association between both polymorphisms and the risk of bladder cancer. Methods: One hundred and ninety-seven patients with bladder cancer and 344 population controls were genotyped and haplotyped for both SNPs. Results: A borderline significantly increased risk for bladder cancer was found for A allele carriers (OR 1.36; 95% CI: 0.96-1.94). We did not find any association between the -347 G/GA SNP and bladder cancer. Haplotype analyses did not yield much stronger associations with bladder cancer than the -160 C/A genotype analyses. Conclusion: This study supports earlier suggestions that the -160 C/A SNP in the CDH1 promoter is a risk factor for bladder cancer.

AB - Aim: E-cadherin plays a role in carcinogenesis. For two genetic polymorphisms in the gene (CDH1) promoter, a reduced transcription has been reported: a C/A single nucleotide polymorphism (SNP) and a G/GA SNP at -160 bp and -347 bp, respectively, upstream of the transcriptional start site. We studied the association between both polymorphisms and the risk of bladder cancer. Methods: One hundred and ninety-seven patients with bladder cancer and 344 population controls were genotyped and haplotyped for both SNPs. Results: A borderline significantly increased risk for bladder cancer was found for A allele carriers (OR 1.36; 95% CI: 0.96-1.94). We did not find any association between the -347 G/GA SNP and bladder cancer. Haplotype analyses did not yield much stronger associations with bladder cancer than the -160 C/A genotype analyses. Conclusion: This study supports earlier suggestions that the -160 C/A SNP in the CDH1 promoter is a risk factor for bladder cancer.

KW - Bladder cancer

KW - E-cadherin promoter

KW - Single nucleotide polymorphisms

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EP - 3227

JO - European Journal of Cancer

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ER -

Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer

Abstract

Keywords

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