Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer

Lambertus A. Kiemeney, Kjeld P. van Houwelingen, Manon Bogaerts, J. Alfred Witjes, Dorine W. Swinkels, Martin den Heijer, Barbara Franke, Jack A. Schalken, Gerald W. Verhaegh

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27 Citations (Scopus)

Abstract

Aim: E-cadherin plays a role in carcinogenesis. For two genetic polymorphisms in the gene (CDH1) promoter, a reduced transcription has been reported: a C/A single nucleotide polymorphism (SNP) and a G/GA SNP at -160 bp and -347 bp, respectively, upstream of the transcriptional start site. We studied the association between both polymorphisms and the risk of bladder cancer. Methods: One hundred and ninety-seven patients with bladder cancer and 344 population controls were genotyped and haplotyped for both SNPs. Results: A borderline significantly increased risk for bladder cancer was found for A allele carriers (OR 1.36; 95% CI: 0.96-1.94). We did not find any association between the -347 G/GA SNP and bladder cancer. Haplotype analyses did not yield much stronger associations with bladder cancer than the -160 C/A genotype analyses. Conclusion: This study supports earlier suggestions that the -160 C/A SNP in the CDH1 promoter is a risk factor for bladder cancer.

Original languageEnglish
Pages (from-to)3219-3227
Number of pages9
JournalEuropean Journal of Cancer
Volume42
Issue number18
DOIs
Publication statusPublished - Dec 2006

Keywords

  • Bladder cancer
  • E-cadherin promoter
  • Single nucleotide polymorphisms

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