Polymorphisms in the Melatonin Receptor 1B Gene and the Risk of Delirium

A. de Jonghe; S. de Rooija; M. W. T. Tanck; E. J. G. Sijbrands; B. C. V. van Munster

doi:https://doi.org/10.1159/000339231

Polymorphisms in the Melatonin Receptor 1B Gene and the Risk of Delirium

A. de Jonghe, S. de Rooija, M. W. T. Tanck, E. J. G. Sijbrands, B. C. V. van Munster

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

Background/Aims: A disturbed sleep-wake rhythm cycle can be seen in delirium and as melatonin regulates this cycle via melatonin receptors, genetic variations in these receptors may contribute to susceptibility to delirium. The purpose of this study was to investigate whether genetic variants in the melatonin receptor 1B (MTNR1B) gene are associated with delirium. Methods: Elderly medical and hip surgery patients were included in the study. Five single-nucleotide polymorphisms (SNPs) were determined in the MTNR1B gene, i.e. rs18030962, rs3781638, rs10830963, rs156244 and rs4753426. Results: In total, 53% of 171 hip fracture patients and 33% of 699 medical patients were diagnosed with delirium. None of the polymorphisms were found to be associated with the occurrence of delirium. Conclusion: Future research could focus on sequencing this gene to look for other functional SNPs in relation to delirium. Copyright (C) 2012 S. Karger AG, Basel

Original language	English
Pages (from-to)	306-310
Journal	Dementia and geriatric cognitive disorders
Volume	33
Issue number	5
DOIs	https://doi.org/10.1159/000339231
Publication status	Published - 2012

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https://doi.org/10.1159/000339231

Cite this

@article{15a36dd26e7640dfacb3a8d79b1ea0ff,

title = "Polymorphisms in the Melatonin Receptor 1B Gene and the Risk of Delirium",

abstract = "Background/Aims: A disturbed sleep-wake rhythm cycle can be seen in delirium and as melatonin regulates this cycle via melatonin receptors, genetic variations in these receptors may contribute to susceptibility to delirium. The purpose of this study was to investigate whether genetic variants in the melatonin receptor 1B (MTNR1B) gene are associated with delirium. Methods: Elderly medical and hip surgery patients were included in the study. Five single-nucleotide polymorphisms (SNPs) were determined in the MTNR1B gene, i.e. rs18030962, rs3781638, rs10830963, rs156244 and rs4753426. Results: In total, 53% of 171 hip fracture patients and 33% of 699 medical patients were diagnosed with delirium. None of the polymorphisms were found to be associated with the occurrence of delirium. Conclusion: Future research could focus on sequencing this gene to look for other functional SNPs in relation to delirium. Copyright (C) 2012 S. Karger AG, Basel",

author = "{de Jonghe}, A. and {de Rooija}, S. and Tanck, {M. W. T.} and Sijbrands, {E. J. G.} and {van Munster}, {B. C. V.}",

year = "2012",

doi = "https://doi.org/10.1159/000339231",

language = "English",

volume = "33",

pages = "306--310",

journal = "Dementia and geriatric cognitive disorders",

issn = "1420-8008",

publisher = "S. Karger AG",

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}

TY - JOUR

T1 - Polymorphisms in the Melatonin Receptor 1B Gene and the Risk of Delirium

AU - de Jonghe, A.

AU - de Rooija, S.

AU - Tanck, M. W. T.

AU - Sijbrands, E. J. G.

AU - van Munster, B. C. V.

PY - 2012

Y1 - 2012

N2 - Background/Aims: A disturbed sleep-wake rhythm cycle can be seen in delirium and as melatonin regulates this cycle via melatonin receptors, genetic variations in these receptors may contribute to susceptibility to delirium. The purpose of this study was to investigate whether genetic variants in the melatonin receptor 1B (MTNR1B) gene are associated with delirium. Methods: Elderly medical and hip surgery patients were included in the study. Five single-nucleotide polymorphisms (SNPs) were determined in the MTNR1B gene, i.e. rs18030962, rs3781638, rs10830963, rs156244 and rs4753426. Results: In total, 53% of 171 hip fracture patients and 33% of 699 medical patients were diagnosed with delirium. None of the polymorphisms were found to be associated with the occurrence of delirium. Conclusion: Future research could focus on sequencing this gene to look for other functional SNPs in relation to delirium. Copyright (C) 2012 S. Karger AG, Basel

AB - Background/Aims: A disturbed sleep-wake rhythm cycle can be seen in delirium and as melatonin regulates this cycle via melatonin receptors, genetic variations in these receptors may contribute to susceptibility to delirium. The purpose of this study was to investigate whether genetic variants in the melatonin receptor 1B (MTNR1B) gene are associated with delirium. Methods: Elderly medical and hip surgery patients were included in the study. Five single-nucleotide polymorphisms (SNPs) were determined in the MTNR1B gene, i.e. rs18030962, rs3781638, rs10830963, rs156244 and rs4753426. Results: In total, 53% of 171 hip fracture patients and 33% of 699 medical patients were diagnosed with delirium. None of the polymorphisms were found to be associated with the occurrence of delirium. Conclusion: Future research could focus on sequencing this gene to look for other functional SNPs in relation to delirium. Copyright (C) 2012 S. Karger AG, Basel

U2 - https://doi.org/10.1159/000339231

DO - https://doi.org/10.1159/000339231

M3 - Article

C2 - 22759724

SN - 1420-8008

VL - 33

SP - 306

EP - 310

JO - Dementia and geriatric cognitive disorders

JF - Dementia and geriatric cognitive disorders

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