TY - JOUR
T1 - Pooling of prognostic studies in cancer of the pancreatic head and periampullary region
T2 - The Triple-P study
AU - Terwee, C. B.
AU - Van Dijkum, E. J.M.N.
AU - Gouma, D. J.
AU - Bakkevold, K. E.
AU - Klinkenbijl, J. H.G.
AU - Wade, T. P.
AU - Van Wagensveld, B. A.
AU - Wong, A.
AU - Van der Meulen, J. H.P.
PY - 2000
Y1 - 2000
N2 - Objective: Development of a prognostic tool for patients with unresectable pancreatic cancer to distinguish between with low or high probabilities of survival 3 to 9 months after diagnosis. Design: Data about individual patients from five studies were pooled. A multivariate proportional hazards model with time-dependent covariates was developed, including age, sex, and metastases. An extended model was developed on a subset of patients, including weight loss, pain, and jaundice at diagnosis. Setting: Multicentre study, The Netherlands; Norway, USA, UK, and Canada. Subjects: 1020 patients with unresectable pancreatic cancer. Main outcome measures: Prediction of prognosis. Results: Patients with metastases, pain, or weight loss at diagnosis had a significantly poorer prognosis than the others. Older men had a worse prognosis than younger men, while older women had a better prognosis than younger ones. Patients with jaundice had a relatively good prognosis. Differences in survival among the studies were incorporated in a prognostic score chart. Conclusion: The prognostic score chart can be used to select patients with relatively low expectation of survival for endoscopic palliation, and patients with relatively high expectation for surgical palliation.
AB - Objective: Development of a prognostic tool for patients with unresectable pancreatic cancer to distinguish between with low or high probabilities of survival 3 to 9 months after diagnosis. Design: Data about individual patients from five studies were pooled. A multivariate proportional hazards model with time-dependent covariates was developed, including age, sex, and metastases. An extended model was developed on a subset of patients, including weight loss, pain, and jaundice at diagnosis. Setting: Multicentre study, The Netherlands; Norway, USA, UK, and Canada. Subjects: 1020 patients with unresectable pancreatic cancer. Main outcome measures: Prediction of prognosis. Results: Patients with metastases, pain, or weight loss at diagnosis had a significantly poorer prognosis than the others. Older men had a worse prognosis than younger men, while older women had a better prognosis than younger ones. Patients with jaundice had a relatively good prognosis. Differences in survival among the studies were incorporated in a prognostic score chart. Conclusion: The prognostic score chart can be used to select patients with relatively low expectation of survival for endoscopic palliation, and patients with relatively high expectation for surgical palliation.
KW - Bypass
KW - Palliative treatment
KW - Pancreatic cancer
KW - Prognostic score
UR - http://www.scopus.com/inward/record.url?scp=0033824457&partnerID=8YFLogxK
U2 - https://doi.org/10.1080/110241500750008466
DO - https://doi.org/10.1080/110241500750008466
M3 - Article
C2 - 11034467
SN - 1102-4151
VL - 166
SP - 706
EP - 712
JO - European journal of surgery
JF - European journal of surgery
IS - 9
ER -