Possible role for cytotoxic lymphocytes in the pathogenesis of acute interstitial nephritis after recombinant interleukin-2 treatment for renal cell cancer

L. T. Vlasveld; E. van de Wiel-van Kemenade; A. J. de Boer; J. J. Sein; M. P. Gallee; R. T. Krediet; C. J. Mellief; E. M. Rankin; A. Hekman; C. G. Figdor

doi:https://doi.org/10.1007/BF01741094

Possible role for cytotoxic lymphocytes in the pathogenesis of acute interstitial nephritis after recombinant interleukin-2 treatment for renal cell cancer

L. T. Vlasveld, E. van de Wiel-van Kemenade, A. J. de Boer, J. J. Sein, M. P. Gallee, R. T. Krediet, C. J. Mellief, E. M. Rankin, A. Hekman, C. G. Figdor

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Research output: Contribution to journal › Comment/Letter to the editor › Academic

6 Citations (Scopus)

Abstract

A patient with renal cell cancer developed acute renal failure due to biopsy-proven acute tubulo-interstitial nephritis (AIN) in the 6th week of continuous infusion of 9 x 10(6) IU m-2 day-1 recombinant interleukin-2 (rIL-2). We investigated whether the AIN was the result of a cellular cytotoxic reaction induced by the rIL-2 treatment. The cytolytic activity of cryopreserved peripheral blood lymphocytes (PBL), isolated before and at the end of the rIL-2 treatment (at the time of AIN), was studied after 5 days of culture with or without rIL-2 or anti-CD28 and immobilized anti-CD3 antibodies. The PBL isolated before and at the end of the rIL-2 treatment showed cytolytic activity towards a number of allogeneic targets. However, only the PBL isolated at the end of the rIL-2 treatment showed, when stimulated with rIL-2 in vitro, significant cytolytic activity against an autologous renal cell line cultured from the AIN biopsy specimen and against an allogeneic renal cell cancer cell line. These PBL displayed no enhanced killing capacity towards autologous PBL and the melanoma cell line M14. These observations suggest that the AIN may be the result of a cytotoxic lymphocyte-mediated reaction induced by the rIL-2 treatment

Original language	English
Pages (from-to)	210-213
Journal	Cancer Immunology, Immunotherapy
Volume	36
Issue number	3
DOIs	https://doi.org/10.1007/BF01741094
Publication status	Published - 1993

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https://doi.org/10.1007/BF01741094

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Vlasveld, L. T., van de Wiel-van Kemenade, E., de Boer, A. J., Sein, J. J., Gallee, M. P., Krediet, R. T., Mellief, C. J., Rankin, E. M., Hekman, A., & Figdor, C. G. (1993). Possible role for cytotoxic lymphocytes in the pathogenesis of acute interstitial nephritis after recombinant interleukin-2 treatment for renal cell cancer. Cancer Immunology, Immunotherapy, 36(3), 210-213. https://doi.org/10.1007/BF01741094

@article{c35d9c1010534d19bddcf217ea1f0db8,

title = "Possible role for cytotoxic lymphocytes in the pathogenesis of acute interstitial nephritis after recombinant interleukin-2 treatment for renal cell cancer",

abstract = "A patient with renal cell cancer developed acute renal failure due to biopsy-proven acute tubulo-interstitial nephritis (AIN) in the 6th week of continuous infusion of 9 x 10(6) IU m-2 day-1 recombinant interleukin-2 (rIL-2). We investigated whether the AIN was the result of a cellular cytotoxic reaction induced by the rIL-2 treatment. The cytolytic activity of cryopreserved peripheral blood lymphocytes (PBL), isolated before and at the end of the rIL-2 treatment (at the time of AIN), was studied after 5 days of culture with or without rIL-2 or anti-CD28 and immobilized anti-CD3 antibodies. The PBL isolated before and at the end of the rIL-2 treatment showed cytolytic activity towards a number of allogeneic targets. However, only the PBL isolated at the end of the rIL-2 treatment showed, when stimulated with rIL-2 in vitro, significant cytolytic activity against an autologous renal cell line cultured from the AIN biopsy specimen and against an allogeneic renal cell cancer cell line. These PBL displayed no enhanced killing capacity towards autologous PBL and the melanoma cell line M14. These observations suggest that the AIN may be the result of a cytotoxic lymphocyte-mediated reaction induced by the rIL-2 treatment",

author = "Vlasveld, {L. T.} and {van de Wiel-van Kemenade}, E. and {de Boer}, {A. J.} and Sein, {J. J.} and Gallee, {M. P.} and Krediet, {R. T.} and Mellief, {C. J.} and Rankin, {E. M.} and A. Hekman and Figdor, {C. G.}",

year = "1993",

doi = "https://doi.org/10.1007/BF01741094",

language = "English",

volume = "36",

pages = "210--213",

journal = "Cancer Immunology, Immunotherapy",

issn = "0340-7004",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "3",

}

Vlasveld, LT, van de Wiel-van Kemenade, E, de Boer, AJ, Sein, JJ, Gallee, MP, Krediet, RT, Mellief, CJ, Rankin, EM, Hekman, A & Figdor, CG 1993, 'Possible role for cytotoxic lymphocytes in the pathogenesis of acute interstitial nephritis after recombinant interleukin-2 treatment for renal cell cancer', Cancer Immunology, Immunotherapy, vol. 36, no. 3, pp. 210-213. https://doi.org/10.1007/BF01741094

Possible role for cytotoxic lymphocytes in the pathogenesis of acute interstitial nephritis after recombinant interleukin-2 treatment for renal cell cancer. / Vlasveld, L. T.; van de Wiel-van Kemenade, E.; de Boer, A. J. et al.
In: Cancer Immunology, Immunotherapy, Vol. 36, No. 3, 1993, p. 210-213.

Research output: Contribution to journal › Comment/Letter to the editor › Academic

TY - JOUR

T1 - Possible role for cytotoxic lymphocytes in the pathogenesis of acute interstitial nephritis after recombinant interleukin-2 treatment for renal cell cancer

AU - Vlasveld, L. T.

AU - van de Wiel-van Kemenade, E.

AU - de Boer, A. J.

AU - Sein, J. J.

AU - Gallee, M. P.

AU - Krediet, R. T.

AU - Mellief, C. J.

AU - Rankin, E. M.

AU - Hekman, A.

AU - Figdor, C. G.

PY - 1993

Y1 - 1993

N2 - A patient with renal cell cancer developed acute renal failure due to biopsy-proven acute tubulo-interstitial nephritis (AIN) in the 6th week of continuous infusion of 9 x 10(6) IU m-2 day-1 recombinant interleukin-2 (rIL-2). We investigated whether the AIN was the result of a cellular cytotoxic reaction induced by the rIL-2 treatment. The cytolytic activity of cryopreserved peripheral blood lymphocytes (PBL), isolated before and at the end of the rIL-2 treatment (at the time of AIN), was studied after 5 days of culture with or without rIL-2 or anti-CD28 and immobilized anti-CD3 antibodies. The PBL isolated before and at the end of the rIL-2 treatment showed cytolytic activity towards a number of allogeneic targets. However, only the PBL isolated at the end of the rIL-2 treatment showed, when stimulated with rIL-2 in vitro, significant cytolytic activity against an autologous renal cell line cultured from the AIN biopsy specimen and against an allogeneic renal cell cancer cell line. These PBL displayed no enhanced killing capacity towards autologous PBL and the melanoma cell line M14. These observations suggest that the AIN may be the result of a cytotoxic lymphocyte-mediated reaction induced by the rIL-2 treatment

AB - A patient with renal cell cancer developed acute renal failure due to biopsy-proven acute tubulo-interstitial nephritis (AIN) in the 6th week of continuous infusion of 9 x 10(6) IU m-2 day-1 recombinant interleukin-2 (rIL-2). We investigated whether the AIN was the result of a cellular cytotoxic reaction induced by the rIL-2 treatment. The cytolytic activity of cryopreserved peripheral blood lymphocytes (PBL), isolated before and at the end of the rIL-2 treatment (at the time of AIN), was studied after 5 days of culture with or without rIL-2 or anti-CD28 and immobilized anti-CD3 antibodies. The PBL isolated before and at the end of the rIL-2 treatment showed cytolytic activity towards a number of allogeneic targets. However, only the PBL isolated at the end of the rIL-2 treatment showed, when stimulated with rIL-2 in vitro, significant cytolytic activity against an autologous renal cell line cultured from the AIN biopsy specimen and against an allogeneic renal cell cancer cell line. These PBL displayed no enhanced killing capacity towards autologous PBL and the melanoma cell line M14. These observations suggest that the AIN may be the result of a cytotoxic lymphocyte-mediated reaction induced by the rIL-2 treatment

U2 - https://doi.org/10.1007/BF01741094

DO - https://doi.org/10.1007/BF01741094

M3 - Comment/Letter to the editor

C2 - 8439983

SN - 0340-7004

VL - 36

SP - 210

EP - 213

JO - Cancer Immunology, Immunotherapy

JF - Cancer Immunology, Immunotherapy

IS - 3

ER -