TY - JOUR
T1 - Post-traumatic stress in adults with 22q11.2 deletion syndrome
AU - von Scheibler, Emma N. M. M.
AU - van Amelsvoort, Thérèse A. M. J.
AU - Vingerhoets, Claudia
AU - van Eeghen, Agnies M.
AU - Boot, Erik
N1 - Funding Information: This work was supported financially by Stichting Wetenschappelijk Onderzoek, ‘s Heeren Loo (#2210100). Publisher Copyright: Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists.
PY - 2022/7/7
Y1 - 2022/7/7
N2 - 22q11.2 deletion syndrome (22q11.2DS) is associated with an elevated genetic risk of several psychiatric disorders. However, the prevalence of post-traumatic stress disorder (PTSD) in individuals with 22q11.2DS has been reported to be only 0.9%; this is lower than that of the general population (3.9%). We explored the occurrence of PTSD and traumatic events in a Dutch cohort of 112 adults with 22q11.2DS, and found PTSD in 8.0%, traumatic events in 20.5% and trauma-focused treatment in 17.9% of patients. Our novel findings suggest that PTSD may be underdiagnosed in individuals with 22q11.2DS. Clinicians and other caregivers should be alert to trauma in this population in order to enable treatment and minimise psychiatric burden.
AB - 22q11.2 deletion syndrome (22q11.2DS) is associated with an elevated genetic risk of several psychiatric disorders. However, the prevalence of post-traumatic stress disorder (PTSD) in individuals with 22q11.2DS has been reported to be only 0.9%; this is lower than that of the general population (3.9%). We explored the occurrence of PTSD and traumatic events in a Dutch cohort of 112 adults with 22q11.2DS, and found PTSD in 8.0%, traumatic events in 20.5% and trauma-focused treatment in 17.9% of patients. Our novel findings suggest that PTSD may be underdiagnosed in individuals with 22q11.2DS. Clinicians and other caregivers should be alert to trauma in this population in order to enable treatment and minimise psychiatric burden.
KW - 22q11.2 deletion syndrome
KW - adults
KW - cognitive-behavioural therapy
KW - eye movement desensitisation reprocessing
KW - post-traumatic stress disorder
UR - http://www.scopus.com/inward/record.url?scp=85133847836&partnerID=8YFLogxK
U2 - https://doi.org/10.1192/bjo.2022.525
DO - https://doi.org/10.1192/bjo.2022.525
M3 - Article
C2 - 35795982
SN - 2056-4724
VL - 8
JO - BJPsych Open
JF - BJPsych Open
IS - 4
M1 - e126
ER -