TY - JOUR
T1 - Potassium intake
T2 - the Cinderella electrolyte
AU - O’Donnell, Martin
AU - Yusuf, Salim
AU - Vogt, Liffert
AU - Mente, Andrew
AU - Messerli, Franz H.
N1 - Funding Information: L.V. has received funding from the Dutch Kidney Foundation (K+onsortium, grant CP1601). Publisher Copyright: © 2023 Oxford University Press. All rights reserved.
PY - 2023/12/14
Y1 - 2023/12/14
N2 - Dietary guidelines recommend intake targets for some essential minerals, based on observational and experimental evidence relating mineral intake levels to health outcomes. For prevention of cardiovascular disease, reducing sodium intake and increasing potassium intake are the principal tools. While reducing sodium intake has received greatest public health priority, emerging evidence suggests that increasing potassium intake may be a more important target for cardiovascular prevention. Increased potassium intake reduces blood pressure and mitigates the hypertensive effects of excess sodium intake, and the recent large Phase III SSaSS trial reported that increasing potassium intake (and reducing sodium intake) in populations with low potassium intake and high sodium intake, through salt substitution (25% KCl, 75%NaCl), reduces the risk of stroke in patients at increased cardiovascular risk. As key sources of potassium intake include fruit, vegetables, nuts, and legumes, higher potassium intake may be associated with healthy dietary patterns. The current review makes the case that increasing potassium intake might represent a more advantageous dietary strategy for prevention of cardiovascular disease. Future research should focus on addressing the independent effect of potassium supplementation in populations with low or moderate potassium intake, and determine effective strategies to increase potassium intake from diet.
AB - Dietary guidelines recommend intake targets for some essential minerals, based on observational and experimental evidence relating mineral intake levels to health outcomes. For prevention of cardiovascular disease, reducing sodium intake and increasing potassium intake are the principal tools. While reducing sodium intake has received greatest public health priority, emerging evidence suggests that increasing potassium intake may be a more important target for cardiovascular prevention. Increased potassium intake reduces blood pressure and mitigates the hypertensive effects of excess sodium intake, and the recent large Phase III SSaSS trial reported that increasing potassium intake (and reducing sodium intake) in populations with low potassium intake and high sodium intake, through salt substitution (25% KCl, 75%NaCl), reduces the risk of stroke in patients at increased cardiovascular risk. As key sources of potassium intake include fruit, vegetables, nuts, and legumes, higher potassium intake may be associated with healthy dietary patterns. The current review makes the case that increasing potassium intake might represent a more advantageous dietary strategy for prevention of cardiovascular disease. Future research should focus on addressing the independent effect of potassium supplementation in populations with low or moderate potassium intake, and determine effective strategies to increase potassium intake from diet.
KW - Cardiovascular
KW - Diet
KW - Potassium
KW - Prevention
UR - http://www.scopus.com/inward/record.url?scp=85180270346&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/eurheartj/ehad628
DO - https://doi.org/10.1093/eurheartj/ehad628
M3 - Review article
C2 - 37936275
SN - 0195-668X
VL - 44
SP - 4925
EP - 4934
JO - European Heart journal
JF - European Heart journal
IS - 47
ER -