TY - JOUR
T1 - Precision medicine in airway diseases: moving to clinical practice
AU - Agustí, Alvar
AU - Bafadhel, Mona
AU - Beasley, Richard
AU - Bel, Elisabeth H.
AU - Faner, Rosa
AU - Gibson, Peter G.
AU - Louis, Renaud
AU - McDonald, Vanessa M.
AU - Sterk, Peter J.
AU - Thomas, Mike
AU - Vogelmeier, Claus
AU - Pavord, Ian D.
PY - 2017
Y1 - 2017
N2 - On February 21, 2017, a European Respiratory Society research seminar held in Barcelona discussed how to best apply precision medicine to chronic airway diseases such as asthma and chronic obstructive pulmonary disease. It is now clear that both are complex and heterogeneous diseases, that often overlap and that both require individualised assessment and treatment. This paper summarises the presentations and discussions that took place during the seminar. Specifically, we discussed the need for a new taxonomy of human diseases, the role of different players in this scenario (exposome, genes, endotypes, phenotypes, biomarkers and treatable traits) and a number of unanswered key questions in the field. We also addressed how to deploy airway precision medicine in clinical practice today, both in primary and specialised care. Finally, we debated the type of research needed to move the field forward. Many common human diseases are still diagnosed as if they are homogeneous entities, using criteria that have hardly changed in a century.. the treatment for diseases that are diagnosed in this way is generic, with empiricism as its cornerstone
AB - On February 21, 2017, a European Respiratory Society research seminar held in Barcelona discussed how to best apply precision medicine to chronic airway diseases such as asthma and chronic obstructive pulmonary disease. It is now clear that both are complex and heterogeneous diseases, that often overlap and that both require individualised assessment and treatment. This paper summarises the presentations and discussions that took place during the seminar. Specifically, we discussed the need for a new taxonomy of human diseases, the role of different players in this scenario (exposome, genes, endotypes, phenotypes, biomarkers and treatable traits) and a number of unanswered key questions in the field. We also addressed how to deploy airway precision medicine in clinical practice today, both in primary and specialised care. Finally, we debated the type of research needed to move the field forward. Many common human diseases are still diagnosed as if they are homogeneous entities, using criteria that have hardly changed in a century.. the treatment for diseases that are diagnosed in this way is generic, with empiricism as its cornerstone
U2 - https://doi.org/10.1183/13993003.01655-2017
DO - https://doi.org/10.1183/13993003.01655-2017
M3 - Article
C2 - 29051276
SN - 0903-1936
VL - 50
SP - 1701655
JO - European respiratory journal
JF - European respiratory journal
IS - 4
ER -