TY - CHAP
T1 - Precision Medicine in Asthma Therapy
AU - Principe, Stefania
AU - Vijverberg, Susanne J. H.
AU - Abdel-Aziz, Mahmoud I.
AU - Scichilone, Nicola
AU - Maitland-van der Zee, Anke H.
N1 - Publisher Copyright: © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2023
Y1 - 2023
N2 - Asthma is a complex, heterogeneous disease that necessitates a proper patient evaluation to decide the correct treatment and optimize disease control. The recent introduction of new target therapies for the most severe form of the disease has heralded a new era of treatment options, intending to treat and control specific molecular pathways in asthma pathophysiology. Precision medicine, using omics sciences, investigates biological and molecular mechanisms to find novel biomarkers that can be used to guide treatment selection and predict response. The identification of reliable biomarkers indicative of the pathological mechanisms in asthma is essential to unravel new potential treatment targets. In this chapter, we provide a general description of the currently available -omics techniques, focusing on their implications in asthma therapy.
AB - Asthma is a complex, heterogeneous disease that necessitates a proper patient evaluation to decide the correct treatment and optimize disease control. The recent introduction of new target therapies for the most severe form of the disease has heralded a new era of treatment options, intending to treat and control specific molecular pathways in asthma pathophysiology. Precision medicine, using omics sciences, investigates biological and molecular mechanisms to find novel biomarkers that can be used to guide treatment selection and predict response. The identification of reliable biomarkers indicative of the pathological mechanisms in asthma is essential to unravel new potential treatment targets. In this chapter, we provide a general description of the currently available -omics techniques, focusing on their implications in asthma therapy.
KW - Asthma
KW - Biomarkers
KW - Omics
KW - Precision medicine
UR - http://www.scopus.com/inward/record.url?scp=85170264966&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/164_2022_598
DO - https://doi.org/10.1007/164_2022_598
M3 - Chapter
C2 - 35852633
VL - 280
T3 - Handbook of Experimental Pharmacology
SP - 85
EP - 106
BT - Handbook of Experimental Pharmacology
PB - Springer Science and Business Media Deutschland GmbH
ER -