@article{d19d4360cc5142c3881416a55d826916,
title = "Predicting negative health outcomes in older general practice patients with chronic illness: Rationale and development of the PROPERmed harmonized individual participant data database",
abstract = "The prevalence of multimorbidity and polypharmacy increases significantly with age and are associated with negative health consequences. However, most current interventions to optimize medication have failed to show significant effects on patient-relevant outcomes. This may be due to ineffectiveness of interventions themselves but may also reflect other factors: insufficient sample sizes, heterogeneity of population. To address this issue, the international PROPERmed collaboration was set up to obtain/synthesize individual participant data (IPD) from five cluster-randomized trials. The trials took place in Germany and The Netherlands and aimed to optimize medication in older general practice patients with chronic illness. PROPERmed is the first database of IPD to be drawn from multiple trials in this patient population and setting. It offers the opportunity to derive prognostic models with increased statistical power for prediction of patient-relevant outcomes resulting from the interplay of multimorbidity and polypharmacy. This may help patients from this heterogeneous group to be stratified according to risk and enable clinicians to identify patients that are likely to benefit most from resource/time-intensive interventions. The aim of this manuscript is to describe the rationale behind PROPERmed collaboration, characteristics of the included studies/participants, development of the harmonized IPD database and challenges faced during this process.",
keywords = "Elderly, Hospitalization, Meta-analysis, Multimorbidity, Polypharmacy, Prognosis, Quality of life",
author = "Gonz{\'a}lez-Gonz{\'a}lez, {Ana I.} and Dinh, {Truc S.} and Meid, {Andreas D.} and Blom, {Jeanet W.} and {van den Akker}, Marjan and Elders, {Petra J.M.} and Ulrich Thiem and {Kuellenberg de Gaudry}, Daniela and Snell, {Kym I.E.} and Rafael Perera and Swart, {Karin M.A.} and Henrik Rudolf and Donna Bosch-Lenders and Trampisch, {Hans Joachim} and Meerpohl, {Joerg J.} and Benno Flaig and Ghainsom Kom and Gerlach, {Ferdinand M.} and Hafaeli, {Walter E.} and Glasziou, {Paul P.} and Christiane Muth",
note = "Funding Information: This work was supported by the German Innovation Fund in accordance with ? 92a (Fortin et al., 2012) Volume V of the Social Insurance Code (? 92a Abs. 2, SGB V - F?nftes Buch Sozialgesetzbuch), grant number: 01VSF16018. The funding body did not play any role in the design of the study and collection, analysis, and interpretation of data, or in writing the manuscript. Andreas D. Meid is funded by the Physician-Scientist Programme of Heidelberg University, Faculty of Medicine. Rafael Perera receives funding from the NIHR Oxford Biomedical Research Council (BRC), the NIHR Oxford Medtech and In-Vitro Diagnostics Co- operative (MIC), the NIHR Applied Research Collaboration (ARC) Oxford and Thames Valley, and the Oxford Martin School. Kym Snell is funded by the National Institute for Health Research School for Primary Care (NIHR SPCR Launching Fellowship). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. Funding Information: This work was supported by the German Innovation Fund in accordance with § 92a ( Fortin et al., 2012 ) Volume V of the Social Insurance Code (§ 92a Abs. 2, SGB V - F{\"u}nftes Buch Sozialgesetzbuch), grant number: 01VSF16018 . The funding body did not play any role in the design of the study and collection, analysis, and interpretation of data, or in writing the manuscript. Andreas D. Meid is funded by the Physician-Scientist Programme of Heidelberg University, Faculty of Medicine . Rafael Perera receives funding from the NIHR Oxford Biomedical Research Council (BRC) , the NIHR Oxford Medtech and In-Vitro Diagnostics Co- operative (MIC) , the NIHR Applied Research Collaboration (ARC) Oxford and Thames Valley , and the Oxford Martin School . Kym Snell is funded by the National Institute for Health Research School for Primary Care (NIHR SPCR Launching Fellowship) . The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",
year = "2021",
month = mar,
day = "1",
doi = "https://doi.org/10.1016/j.mad.2021.111436",
language = "English",
volume = "194",
journal = "Mechanisms of ageing and development",
issn = "0047-6374",
publisher = "Elsevier Ireland Ltd",
}