Predictive value of mild cognitive impairment for dementia. The influence of case definition and age

M.A. Baars; M.P. van Boxtel; J.B. Dijkstra; P.J. Visser; M. van den Akker; F.R.J. Verhey; J. Jolles

doi:https://doi.org/10.1159/000200465

Predictive value of mild cognitive impairment for dementia. The influence of case definition and age

M.A. Baars, M.P. van Boxtel, J.B. Dijkstra, P.J. Visser, M. van den Akker, F.R.J. Verhey, J. Jolles

Neurology (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

61 Citations (Scopus)

Abstract

Background/Aims: In population studies, different mild cognitive impairment (MCI) definitions have been used to predict dementia at a later stage. This study compared predictive values of different MCI definitions for dementia, and the effect of age on the predictive values was investigated. Methods: This study was conducted as part of an ongoing longitudinal study into the determinants of cognitive aging, the Maastricht Aging Study. Results: MCI best predicted dementia when multiple cognitive domains were considered and subjective complaints were not (sensitivity: 0.66, specificity: 0.78). Age had a strong influence on the sensitivity of MCI for dementia (age 60-70 years: sensitivity = 0.56; age 70-85 years: sensitivity = 0.70). Conclusion: The inclusion of multiple cognitive domains and participants aged 70 years and older leads to the best prediction of dementia, regardless of subjective complaints. Copyright © 2009 S. Karger AG.

Original language	English
Pages (from-to)	173-181
Journal	Dementia and geriatric cognitive disorders
Volume	27
Issue number	2
DOIs	https://doi.org/10.1159/000200465
Publication status	Published - 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1159/000200465

Cite this

@article{1b5444b14d7a4a9aa2af69b5e2b873e5,

title = "Predictive value of mild cognitive impairment for dementia. The influence of case definition and age",

abstract = "Background/Aims: In population studies, different mild cognitive impairment (MCI) definitions have been used to predict dementia at a later stage. This study compared predictive values of different MCI definitions for dementia, and the effect of age on the predictive values was investigated. Methods: This study was conducted as part of an ongoing longitudinal study into the determinants of cognitive aging, the Maastricht Aging Study. Results: MCI best predicted dementia when multiple cognitive domains were considered and subjective complaints were not (sensitivity: 0.66, specificity: 0.78). Age had a strong influence on the sensitivity of MCI for dementia (age 60-70 years: sensitivity = 0.56; age 70-85 years: sensitivity = 0.70). Conclusion: The inclusion of multiple cognitive domains and participants aged 70 years and older leads to the best prediction of dementia, regardless of subjective complaints. Copyright {\textcopyright} 2009 S. Karger AG.",

author = "M.A. Baars and {van Boxtel}, M.P. and J.B. Dijkstra and P.J. Visser and {van den Akker}, M. and F.R.J. Verhey and J. Jolles",

year = "2009",

doi = "https://doi.org/10.1159/000200465",

language = "English",

volume = "27",

pages = "173--181",

journal = "Dementia and geriatric cognitive disorders",

issn = "1420-8008",

publisher = "S. Karger AG",

number = "2",

}

TY - JOUR

T1 - Predictive value of mild cognitive impairment for dementia. The influence of case definition and age

AU - Baars, M.A.

AU - van Boxtel, M.P.

AU - Dijkstra, J.B.

AU - Visser, P.J.

AU - van den Akker, M.

AU - Verhey, F.R.J.

AU - Jolles, J.

PY - 2009

Y1 - 2009

N2 - Background/Aims: In population studies, different mild cognitive impairment (MCI) definitions have been used to predict dementia at a later stage. This study compared predictive values of different MCI definitions for dementia, and the effect of age on the predictive values was investigated. Methods: This study was conducted as part of an ongoing longitudinal study into the determinants of cognitive aging, the Maastricht Aging Study. Results: MCI best predicted dementia when multiple cognitive domains were considered and subjective complaints were not (sensitivity: 0.66, specificity: 0.78). Age had a strong influence on the sensitivity of MCI for dementia (age 60-70 years: sensitivity = 0.56; age 70-85 years: sensitivity = 0.70). Conclusion: The inclusion of multiple cognitive domains and participants aged 70 years and older leads to the best prediction of dementia, regardless of subjective complaints. Copyright © 2009 S. Karger AG.

AB - Background/Aims: In population studies, different mild cognitive impairment (MCI) definitions have been used to predict dementia at a later stage. This study compared predictive values of different MCI definitions for dementia, and the effect of age on the predictive values was investigated. Methods: This study was conducted as part of an ongoing longitudinal study into the determinants of cognitive aging, the Maastricht Aging Study. Results: MCI best predicted dementia when multiple cognitive domains were considered and subjective complaints were not (sensitivity: 0.66, specificity: 0.78). Age had a strong influence on the sensitivity of MCI for dementia (age 60-70 years: sensitivity = 0.56; age 70-85 years: sensitivity = 0.70). Conclusion: The inclusion of multiple cognitive domains and participants aged 70 years and older leads to the best prediction of dementia, regardless of subjective complaints. Copyright © 2009 S. Karger AG.

U2 - https://doi.org/10.1159/000200465

DO - https://doi.org/10.1159/000200465

M3 - Article

C2 - 19202336

SN - 1420-8008

VL - 27

SP - 173

EP - 181

JO - Dementia and geriatric cognitive disorders

JF - Dementia and geriatric cognitive disorders

IS - 2

ER -