@article{fc43f97fca5447578fb05ef7e4e62f3c,
title = "Predictors of engagement with remote sensing technologies for symptom measurement in Major Depressive Disorder",
abstract = "Background: Remote sensing for the measurement and management of long-term conditions such as Major Depressive Disorder (MDD) is becoming more prevalent. User-engagement is essential to yield any benefits. We tested three hypotheses examining associations between clinical characteristics, perceptions of remote sensing, and objective user engagement metrics. Methods: The Remote Assessment of Disease and Relapse – Major Depressive Disorder (RADAR-MDD) study is a multicentre longitudinal observational cohort study in people with recurrent MDD. Participants wore a FitBit and completed app-based assessments every two weeks for a median of 18 months. Multivariable random effects regression models pooling data across timepoints were used to examine associations between variables. Results: A total of 547 participants (87.8% of the total sample) were included in the current analysis. Higher levels of anxiety were associated with lower levels of perceived technology ease of use; increased functional disability was associated with small differences in perceptions of technology usefulness and usability. Participants who reported higher system ease of use, usefulness, and acceptability subsequently completed more app-based questionnaires and tended to wear their FitBit activity tracker for longer. All effect sizes were small and unlikely to be of practical significance. Limitations: Symptoms of depression, anxiety, functional disability, and perceptions of system usability are measured at the same time. These therefore represent cross-sectional associations rather than predictions of future perceptions. Conclusions: These findings suggest that perceived usability and actual use of remote measurement technologies in people with MDD are robust across differences in severity of depression, anxiety, and functional impairment.",
keywords = "Cohort study, Engagement, Major Depressive Disorder, Predictors, Remote sensing",
author = "{RADAR-CNS Consortium} and F. Matcham and E. Carr and White, {K. M.} and D. Leightley and F. Lamers and S. Siddi and P. Annas and {de Girolamo}, G. and Haro, {J. M.} and M. Horsfall and A. Ivan and G. Lavelle and Q. Li and F. Lombardini and Mohr, {D. C.} and Narayan, {V. A.} and Penninx, {B. W.H.J.} and C. Oetzmann and M. Coromina and Simblett, {S. K.} and J. Weyer and T. Wykes and S. Zorbas and Brasen, {J. C.} and I. Myin-Germeys and P. Conde and Dobson, {R. J.B.} and Folarin, {A. A.} and Y. Ranjan and Z. Rashid and N. Cummins and J. Dineley and S. Vairavan and M. Hotopf",
note = "Funding Information: The RADAR-CNS project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115902 . This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA ( www.imi.europa.eu ). Funding Information: This paper represents independent research part funded by the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London . The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. Funding Information: Participant recruitment in Amsterdam was partially accomplished through Hersenonderzoek.nl, a Dutch online registry that facilitates participant recruitment for neuroscience studies ( https://hersenonderzoek.nl/ ). Hersenonderzoek.nl is funded by ZonMw-Memorabel (project no 73305095003), a project in the context of the Dutch Deltaplan Dementie, Gieskes-Strijbis Foundation, the Alzheimer's Society in the Netherlands and Brain Foundation Netherlands. Funding Information: Participant recruitment in Amsterdam was partially accomplished through Hersenonderzoek.nl, a Dutch online registry that facilitates participant recruitment for neuroscience studies (https://hersenonderzoek.nl/). Hersenonderzoek.nl is funded by ZonMw-Memorabel (project no 73305095003), a project in the context of the Dutch Deltaplan Dementie, Gieskes-Strijbis Foundation, the Alzheimer's Society in the Netherlands and Brain Foundation Netherlands. Participants in Spain were recruited through the following institutions: Parc Sanitari Sant Joan de D{\'e}u network of mental health services (Barcelona); Institut Catal{\`a} de la Salut primary care services (Barcelona); Institut Pere Mata-Mental Health Care (Terrassa); Hospital Cl{\'i}nico San Carlos (Madrid). We thank all the members of the RADAR-CNS patient advisory board for their contribution to the device selection procedures, and their invaluable advice throughout the study protocol design. This research was reviewed by a team with experience of mental health problems and their carers who have been specially trained to advise on research proposals and documentation through the Feasibility and Acceptability Support Team for Researchers (FAST-R): a free, confidential service in England provided by the National Institute for Health Research Maudsley Biomedical Research Centre via King's College London and South London and Maudsley NHS Foundation Trust. We thank all GLAD Study volunteers for their participation, and gratefully acknowledge the NIHR BioResource, NIHR BioResource centres, NHS Trusts and staff for their contribution. We also acknowledge NIHR BRC, King's College London, South London and Maudsley NHS Trust and King's Health Partners. We thank the National Institute for Health Research, NHS Blood and Transplant, and Health Data Research UK as part of the Digital Innovation Hub Programme. The RADAR-CNS project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115902. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA (www.imi.europa.eu). This paper represents independent research part funded by the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",
year = "2022",
month = aug,
day = "1",
doi = "https://doi.org/10.1016/j.jad.2022.05.005",
language = "English",
volume = "310",
pages = "106--115",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
}