Preparation of leucocyte-poor platelet concentrates from buffy coats. IV. Clinical evaluation

R. N. Pietersz; H. W. Reesink; P. C. Huijgens; M. H. van Oers

doi:https://doi.org/10.1111/j.1423-0410.1988.tb05078.x

Preparation of leucocyte-poor platelet concentrates from buffy coats. IV. Clinical evaluation

R. N. Pietersz, H. W. Reesink, P. C. Huijgens, M. H. van Oers

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Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

To study survival and function of leukocyte-poor platelet concentrates (lp-PC) prepared from buffy coats, random platelet transfusions requested for thrombocytopenic patients were evaluated. The lp-PC issued were stored at 22 degrees C for either 1, 3 or 5 days before transfusion. From 31 transfusions, posttransfusion corrected count increments (CCI), corrected for body surface (m2) and divided by number of platelets transfused (1011), were calculated. The mean +/- SEM of the 1-, 24- and 48- hour CCI was 12.2 +/- 0.45, 11.2 +/- 0.51 and 8.8 +/- 0.58, respectively. No significant differences in CCI 24 h after transfusion were observed for 1p-PC stored for 1, 3 or 5 days. Hemostatic activity was observed in all 9 evaluable patients. It is concluded that platelets from 1p-PC survive well in patients, regardless of storage for 1, 3 or 5 days and that the platelets are hemostatically active after transfusion

Original language	English
Pages (from-to)	129-132
Journal	Vox sanguinis
Volume	55
Issue number	3
DOIs	https://doi.org/10.1111/j.1423-0410.1988.tb05078.x
Publication status	Published - 1988

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https://doi.org/10.1111/j.1423-0410.1988.tb05078.x

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@article{2a7d6ef2201e4c409814be163da94293,

title = "Preparation of leucocyte-poor platelet concentrates from buffy coats. IV. Clinical evaluation",

abstract = "To study survival and function of leukocyte-poor platelet concentrates (lp-PC) prepared from buffy coats, random platelet transfusions requested for thrombocytopenic patients were evaluated. The lp-PC issued were stored at 22 degrees C for either 1, 3 or 5 days before transfusion. From 31 transfusions, posttransfusion corrected count increments (CCI), corrected for body surface (m2) and divided by number of platelets transfused (1011), were calculated. The mean +/- SEM of the 1-, 24- and 48- hour CCI was 12.2 +/- 0.45, 11.2 +/- 0.51 and 8.8 +/- 0.58, respectively. No significant differences in CCI 24 h after transfusion were observed for 1p-PC stored for 1, 3 or 5 days. Hemostatic activity was observed in all 9 evaluable patients. It is concluded that platelets from 1p-PC survive well in patients, regardless of storage for 1, 3 or 5 days and that the platelets are hemostatically active after transfusion",

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T1 - Preparation of leucocyte-poor platelet concentrates from buffy coats. IV. Clinical evaluation

AU - Pietersz, R. N.

AU - Reesink, H. W.

AU - Huijgens, P. C.

AU - van Oers, M. H.

PY - 1988

Y1 - 1988

N2 - To study survival and function of leukocyte-poor platelet concentrates (lp-PC) prepared from buffy coats, random platelet transfusions requested for thrombocytopenic patients were evaluated. The lp-PC issued were stored at 22 degrees C for either 1, 3 or 5 days before transfusion. From 31 transfusions, posttransfusion corrected count increments (CCI), corrected for body surface (m2) and divided by number of platelets transfused (1011), were calculated. The mean +/- SEM of the 1-, 24- and 48- hour CCI was 12.2 +/- 0.45, 11.2 +/- 0.51 and 8.8 +/- 0.58, respectively. No significant differences in CCI 24 h after transfusion were observed for 1p-PC stored for 1, 3 or 5 days. Hemostatic activity was observed in all 9 evaluable patients. It is concluded that platelets from 1p-PC survive well in patients, regardless of storage for 1, 3 or 5 days and that the platelets are hemostatically active after transfusion

AB - To study survival and function of leukocyte-poor platelet concentrates (lp-PC) prepared from buffy coats, random platelet transfusions requested for thrombocytopenic patients were evaluated. The lp-PC issued were stored at 22 degrees C for either 1, 3 or 5 days before transfusion. From 31 transfusions, posttransfusion corrected count increments (CCI), corrected for body surface (m2) and divided by number of platelets transfused (1011), were calculated. The mean +/- SEM of the 1-, 24- and 48- hour CCI was 12.2 +/- 0.45, 11.2 +/- 0.51 and 8.8 +/- 0.58, respectively. No significant differences in CCI 24 h after transfusion were observed for 1p-PC stored for 1, 3 or 5 days. Hemostatic activity was observed in all 9 evaluable patients. It is concluded that platelets from 1p-PC survive well in patients, regardless of storage for 1, 3 or 5 days and that the platelets are hemostatically active after transfusion

U2 - https://doi.org/10.1111/j.1423-0410.1988.tb05078.x

DO - https://doi.org/10.1111/j.1423-0410.1988.tb05078.x

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SN - 0042-9007

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JO - Vox sanguinis

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