Preparation of Next-Generation Sequencing Libraries for Sequencing Circulating DNA

Katrin Heider, Florent Mouliere, Christopher G. Smith

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

Next-generation sequencing of circulating DNA brings a set of challenges distinct to sequencing genomic DNA, stemming largely from its low-concentration and heavily fragmented nature. This chapter considers different approaches to sequencing library preparation, and how these are tailored to circulating DNA analysis.
Original languageEnglish
Title of host publicationCell-Free Circulating DNA
Subtitle of host publicationPurification and Analysis Techniques
PublisherWorld Scientific Publishing Co.
Pages139-173
Number of pages35
ISBN (Electronic)9789811244681
ISBN (Print)9789811244674
DOIs
Publication statusPublished - 1 Jan 2022

Publication series

NameCell-Free Circulating DNA: Purification and Analysis Techniques

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