TY - JOUR
T1 - Prevalence of RIB anomalies in normal Caucasian children and childhood cancer patients
AU - Merks, Johannes H. M.
AU - Smets, Anne M.
AU - van Rijn, Rick R.
AU - Kobes, Jasmijn
AU - Caron, Huib N.
AU - Maas, Mario
AU - Hennekam, Raoul C. M.
PY - 2005
Y1 - 2005
N2 - Purpose. - To evaluate the prevalence of abnormalities of rib development in normal Caucasian children and patients with childhood cancer. Materials And Methods. - Chest radiographs of 881 Caucasian pediatric controls and 906 childhood cancer patients were reviewed, and independently scored by four blinded observers, using strict definitions. Prevalences of 6 major rib anomaly categories in controls were compared to their prevalence in the total group of childhood cancer patients, and the 12 individual larger tumor groups using Chi-square tests. Results. - Values in the control population were generated for the occurrence of six major rib anomaly categories; cervical rib anomalies were present in 6.1% of controls, aplasia of 12(th) ribs in 6.6%, lumbar ribs in 0.9%, bifurcations in 0.7%, synostosis-bridging in 0.3%, and segmentations were not found. The overall prevalence of total rib anomalies in cases and controls was equal (14.9% and 14.2%, respectively). Cervical rib anomalies were found significantly more often in cases (8.6%) compared to controls (p-value=0.047), three groups accounting for this higher prevalence: 12.1% of acute lymphoblastic leukemia patients (p=0.011), 18.2% of astrocytoma patients (p=0.023), and 14.7% of germ cell tumor patients (p=0.046) had a cervical rib anomaly. Conclusion. - Prevalence figures for the presence and type of rib anomalies in a large group of normal Caucasian children were generated. In childhood cancer patients a significantly higher prevalence of cervical rib anomalies was demonstrated in patients with acute lymphoblastic leukemia, astrocytoma, and germ cell tumors. (c) 2004 Elsevier SAS. All rights reserved
AB - Purpose. - To evaluate the prevalence of abnormalities of rib development in normal Caucasian children and patients with childhood cancer. Materials And Methods. - Chest radiographs of 881 Caucasian pediatric controls and 906 childhood cancer patients were reviewed, and independently scored by four blinded observers, using strict definitions. Prevalences of 6 major rib anomaly categories in controls were compared to their prevalence in the total group of childhood cancer patients, and the 12 individual larger tumor groups using Chi-square tests. Results. - Values in the control population were generated for the occurrence of six major rib anomaly categories; cervical rib anomalies were present in 6.1% of controls, aplasia of 12(th) ribs in 6.6%, lumbar ribs in 0.9%, bifurcations in 0.7%, synostosis-bridging in 0.3%, and segmentations were not found. The overall prevalence of total rib anomalies in cases and controls was equal (14.9% and 14.2%, respectively). Cervical rib anomalies were found significantly more often in cases (8.6%) compared to controls (p-value=0.047), three groups accounting for this higher prevalence: 12.1% of acute lymphoblastic leukemia patients (p=0.011), 18.2% of astrocytoma patients (p=0.023), and 14.7% of germ cell tumor patients (p=0.046) had a cervical rib anomaly. Conclusion. - Prevalence figures for the presence and type of rib anomalies in a large group of normal Caucasian children were generated. In childhood cancer patients a significantly higher prevalence of cervical rib anomalies was demonstrated in patients with acute lymphoblastic leukemia, astrocytoma, and germ cell tumors. (c) 2004 Elsevier SAS. All rights reserved
U2 - https://doi.org/10.1016/j.ejmg.2005.01.029
DO - https://doi.org/10.1016/j.ejmg.2005.01.029
M3 - Article
C2 - 16053903
SN - 1769-7212
VL - 48
SP - 113
EP - 129
JO - European journal of medical genetics
JF - European journal of medical genetics
IS - 2
ER -