TY - JOUR
T1 - Primary and pollen-associated hazelnut allergy in school-aged children in Germany: A birth cohort study
AU - Erhard, Sina M.
AU - Bellach, Johanna
AU - Yürek, Songül
AU - Tschirner, Sebastian
AU - Trendelenburg, Valérie
AU - Grabenhenrich, Linus B.
AU - Fernandez-Rivas, Montserrat
AU - van Ree, Ronald
AU - Keil, Thomas
AU - Beyer, Kirsten
N1 - Funding Information: The birth cohort study was funded by the European Commission: (i) under the 6th Framework Programme ( FOOD-CT-2005-514000 ) within the collaborative research initiative ‘EuroPrevall‘, and (ii) under the 7th Framework Programme (FP7-KBBE-2012-6; grant agreement no. 312147 ) within the collaborative project ‘iFAAM‘. The funding body had no influence on the study design, data analysis, interpretation of results, or manuscript preparation. Funding Information: We thank all families who participated in the birth cohort study and the medical and nursing staff, especially S. Paschke-Goossens, G. Schulz, A. Rohrbach, T. Schrezenmaier, and A. Scholz. Furthermore, we thank A. Reich, K. Icke and D. McBride for their contributions regarding data management, study coordination and participation in the design of the birth cohort. We also wish to thank Clare Mills as the overall coordinator of the European collaborative research initiatives EuroPrevall and iFAAM, and Phil Couch who was responsible for all central IT aspects of the birth cohort follow-up assessment in school-age. The birth cohort study was funded by the European Commission: (i) under the 6th Framework Programme (FOOD-CT-2005-514000) within the collaborative research initiative ?EuroPrevall?, and (ii) under the 7th Framework Programme (FP7-KBBE-2012-6; grant agreement no. 312147) within the collaborative project ?iFAAM?. The funding body had no influence on the study design, data analysis, interpretation of results, or manuscript preparation. Publisher Copyright: © 2021 Japanese Society of Allergology
PY - 2021/10
Y1 - 2021/10
N2 - Background: Primary hazelnut allergy is a common cause of anaphylaxis in children, as compared to birch-pollen associated hazelnut allergy. Population-based data on hazelnut and concomitant birch-pollen allergy in children are lacking. We aimed to investigate the prevalence of primary and pollen-associated hazelnut allergy and sensitization profiles in school-aged children in Berlin, Germany. Methods: 1570 newborn children were recruited in Berlin in 2005–2009. The school-age follow-up (2014–2017) was based on a standardized web-based parental questionnaire and clinical evaluation by a physician including skin prick tests, allergen specific immunoglobulin E serum tests and placebo-controlled double-blind oral food challenges, if indicated. Results: 1004 children (63.9% response) participated in the school-age follow-up assessment (52.1% male). For 1.9% (n = 19, 95%-confidence interval 1.1%–2.9%) of children their parents reported hazelnut-allergic symptoms, for half of these to roasted hazelnut indicating primary hazelnut allergy. Symptoms of birch-pollen allergy were reported for 11.6% (n = 116 95%-CI 9.7%–13.7%) of the children. Both birch-pollen allergy and hazelnut allergy associated symptoms affected 0.6% (n = 6, 95%-CI 0.2%–1.3%) of children. Assessment of allergic sensitization was performed in 261 participants and showed that almost 20% of these children were sensitized to hazelnut, being the most frequent of all assessed food allergens, or birch-pollen, the majority to both. Conclusions: Based on parental reports hazelnut-allergic symptoms were far less common than sensitization to hazelnut. This needs to be considered by physicians to avoid unnecessary changes in diet due to sensitization profiles only, especially when there is a co-sensitization to hazelnut and birch-pollen.
AB - Background: Primary hazelnut allergy is a common cause of anaphylaxis in children, as compared to birch-pollen associated hazelnut allergy. Population-based data on hazelnut and concomitant birch-pollen allergy in children are lacking. We aimed to investigate the prevalence of primary and pollen-associated hazelnut allergy and sensitization profiles in school-aged children in Berlin, Germany. Methods: 1570 newborn children were recruited in Berlin in 2005–2009. The school-age follow-up (2014–2017) was based on a standardized web-based parental questionnaire and clinical evaluation by a physician including skin prick tests, allergen specific immunoglobulin E serum tests and placebo-controlled double-blind oral food challenges, if indicated. Results: 1004 children (63.9% response) participated in the school-age follow-up assessment (52.1% male). For 1.9% (n = 19, 95%-confidence interval 1.1%–2.9%) of children their parents reported hazelnut-allergic symptoms, for half of these to roasted hazelnut indicating primary hazelnut allergy. Symptoms of birch-pollen allergy were reported for 11.6% (n = 116 95%-CI 9.7%–13.7%) of the children. Both birch-pollen allergy and hazelnut allergy associated symptoms affected 0.6% (n = 6, 95%-CI 0.2%–1.3%) of children. Assessment of allergic sensitization was performed in 261 participants and showed that almost 20% of these children were sensitized to hazelnut, being the most frequent of all assessed food allergens, or birch-pollen, the majority to both. Conclusions: Based on parental reports hazelnut-allergic symptoms were far less common than sensitization to hazelnut. This needs to be considered by physicians to avoid unnecessary changes in diet due to sensitization profiles only, especially when there is a co-sensitization to hazelnut and birch-pollen.
KW - Birch-pollen
KW - Epidemiology
KW - Food allergy
KW - Hazelnut
KW - Seasonal allergic rhinitis
UR - http://www.scopus.com/inward/record.url?scp=85108589637&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.alit.2021.05.006
DO - https://doi.org/10.1016/j.alit.2021.05.006
M3 - Article
C2 - 34175213
SN - 1323-8930
VL - 70
SP - 463
EP - 470
JO - Allergology International
JF - Allergology International
IS - 4
ER -