TY - JOUR
T1 - Primary brain tumours, meningiomas and brain metastases in pregnancy: Report on 27 cases and review of literature
AU - Verheecke, Magali
AU - Halaska, Michael J.
AU - Lok, Christianne A.
AU - Ottevanger, Petronella B.
AU - Fruscio, Robert
AU - Dahl-Steffensen, Karina
AU - Kolawa, Wojciech
AU - Gziri, Mina Mhallem
AU - Han, Sileny Naeyu
AU - van Calsteren, Kristel
AU - van den Heuvel, Frank
AU - de Vleeschouwer, Steven
AU - Clement, Paul M.
AU - Menten, Johannes
AU - Amant, Frédéric
PY - 2014
Y1 - 2014
N2 - Background: The concurrence of intracranial tumours with pregnancy is rare. The purpose of this study was to describe all reported patients registered in the international Cancer in Pregnancy registration study (CIP study; http://www.cancerinpregnancy.org), and to review the literature in order to obtain better insight into outcome and possibilities of treatment in pregnancy. Methods: We collected all intracranial tumours (primary brain tumour, cerebral metastasis, or meningioma) diagnosed during pregnancy, registered prospectively and retrospectively by international collaboration since 1973. Patients diagnosed postpartum were excluded. We summarised the demographic features, treatment decisions, obstetrical and neonatal outcomes. Results: The mean age of the 27 eligible patients was 31 years (range 23-41 years), of which 13 and 12 patients were diagnosed in the second and third trimesters, respectively. Eight patients (30%) underwent brain surgery, seven patients (26%) had radiotherapy and in three patients (11%) chemotherapy was administered during gestation. Two patients died during pregnancy and four pregnancies were terminated. In 16 (59%) patients elective caesarean section was performed of which 14 (52%) were still preterm (range 30-36 weeks, mean 33 weeks). Five patients had a vaginal delivery (range 36-40 weeks). Of the 21 ongoing pregnancies all children were born alive without visible congenital malformations and the available long-term follow-up data (range 2-25 years) of six children were reassuring. Conclusion: Adherence to standard protocol for the treatment of brain tumours during pregnancy appears to allow a term delivery and a higher probability of a vaginal delivery. (C) 2014 Elsevier Ltd. All rights reserved
AB - Background: The concurrence of intracranial tumours with pregnancy is rare. The purpose of this study was to describe all reported patients registered in the international Cancer in Pregnancy registration study (CIP study; http://www.cancerinpregnancy.org), and to review the literature in order to obtain better insight into outcome and possibilities of treatment in pregnancy. Methods: We collected all intracranial tumours (primary brain tumour, cerebral metastasis, or meningioma) diagnosed during pregnancy, registered prospectively and retrospectively by international collaboration since 1973. Patients diagnosed postpartum were excluded. We summarised the demographic features, treatment decisions, obstetrical and neonatal outcomes. Results: The mean age of the 27 eligible patients was 31 years (range 23-41 years), of which 13 and 12 patients were diagnosed in the second and third trimesters, respectively. Eight patients (30%) underwent brain surgery, seven patients (26%) had radiotherapy and in three patients (11%) chemotherapy was administered during gestation. Two patients died during pregnancy and four pregnancies were terminated. In 16 (59%) patients elective caesarean section was performed of which 14 (52%) were still preterm (range 30-36 weeks, mean 33 weeks). Five patients had a vaginal delivery (range 36-40 weeks). Of the 21 ongoing pregnancies all children were born alive without visible congenital malformations and the available long-term follow-up data (range 2-25 years) of six children were reassuring. Conclusion: Adherence to standard protocol for the treatment of brain tumours during pregnancy appears to allow a term delivery and a higher probability of a vaginal delivery. (C) 2014 Elsevier Ltd. All rights reserved
U2 - https://doi.org/10.1016/j.ejca.2014.02.018
DO - https://doi.org/10.1016/j.ejca.2014.02.018
M3 - Review article
C2 - 24636876
SN - 0959-8049
VL - 50
SP - 1462
EP - 1471
JO - European journal of cancer (Oxford, England
JF - European journal of cancer (Oxford, England
IS - 8
ER -