Primary Management of Operable Locally Advanced Oral Cavity Squamous Cell Carcinoma: Current Concepts and Strategies

Ameya A Asarkar; Brent A Chang; Remco de Bree; Luiz P Kowalski; Orlando Guntinas-Lichius; Patrick J Bradley; Pim de Graaf; Primož Strojan; Karthik N Rao; Antti A Mäkitie; Fernando López; Alessandra Rinaldo; Carsten Palme; Eric M Genden; Alvaro Sanabria; Juan P Rodrigo; Alfio Ferlito

doi:10.1007/s12325-024-02861-6

Primary Management of Operable Locally Advanced Oral Cavity Squamous Cell Carcinoma: Current Concepts and Strategies

Ameya A Asarkar, Brent A Chang, Remco de Bree, Luiz P Kowalski, Orlando Guntinas-Lichius, Patrick J Bradley, Pim de Graaf, Primož Strojan, Karthik N Rao, Antti A Mäkitie, Fernando López, Alessandra Rinaldo, Carsten Palme, Eric M Genden, Alvaro Sanabria, Juan P Rodrigo, Alfio Ferlito

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

INTRODUCTION: Locally advanced oral cavity carcinoma (LAOCSCC) is primarily treated with surgery followed by radiotherapy with or without chemotherapy.

METHODS: A review of literature using PubMED was performed for studies reporting the management of LAOCSCC. Based on the reviewed literature and opinions of experts in the field, recommendations were made.

RESULTS: Studies have shown that outcomes following resection of T4a and infranotch (inferior to mandibular notch) T4b are comparable. We discuss the concept of compartmental resection of LAOCSCC and issues concerning the management of the neck. Further, patients who refuse or are unable to undergo surgery can be treated with chemoradiotherapy with uncertain outcomes. The role of neoadjuvant chemotherapy has shown promise for organ (mandibular) preservation in a select subset of patients.

CONCLUSION: The management strategy for LAOCSCC should be determined in a multidisciplinary setting with emphasis on tumor control, functional preservation, and quality of life of the patient.

Original language	English
Journal	Advances in therapy
Early online date	20 Apr 2024
DOIs	https://doi.org/10.1007/s12325-024-02861-6
Publication status	E-pub ahead of print - 20 Apr 2024

Keywords

Margins
Neoadjuvant chemotherapy, surgery
Oral cavity squamous cell carcinoma
TNM

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Asarkar, A. A., Chang, B. A., de Bree, R., Kowalski, L. P., Guntinas-Lichius, O., Bradley, P. J., de Graaf, P., Strojan, P., Rao, K. N., Mäkitie, A. A., López, F., Rinaldo, A., Palme, C., Genden, E. M., Sanabria, A., Rodrigo, J. P., & Ferlito, A. (2024). Primary Management of Operable Locally Advanced Oral Cavity Squamous Cell Carcinoma: Current Concepts and Strategies. Advances in therapy. Advance online publication. https://doi.org/10.1007/s12325-024-02861-6

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title = "Primary Management of Operable Locally Advanced Oral Cavity Squamous Cell Carcinoma: Current Concepts and Strategies",

abstract = "INTRODUCTION: Locally advanced oral cavity carcinoma (LAOCSCC) is primarily treated with surgery followed by radiotherapy with or without chemotherapy.METHODS: A review of literature using PubMED was performed for studies reporting the management of LAOCSCC. Based on the reviewed literature and opinions of experts in the field, recommendations were made.RESULTS: Studies have shown that outcomes following resection of T4a and infranotch (inferior to mandibular notch) T4b are comparable. We discuss the concept of compartmental resection of LAOCSCC and issues concerning the management of the neck. Further, patients who refuse or are unable to undergo surgery can be treated with chemoradiotherapy with uncertain outcomes. The role of neoadjuvant chemotherapy has shown promise for organ (mandibular) preservation in a select subset of patients.CONCLUSION: The management strategy for LAOCSCC should be determined in a multidisciplinary setting with emphasis on tumor control, functional preservation, and quality of life of the patient.",

keywords = "Margins, Neoadjuvant chemotherapy, surgery, Oral cavity squamous cell carcinoma, TNM",

author = "Asarkar, {Ameya A} and Chang, {Brent A} and {de Bree}, Remco and Kowalski, {Luiz P} and Orlando Guntinas-Lichius and Bradley, {Patrick J} and {de Graaf}, Pim and Primo{\v z} Strojan and Rao, {Karthik N} and M{\"a}kitie, {Antti A} and Fernando L{\'o}pez and Alessandra Rinaldo and Carsten Palme and Genden, {Eric M} and Alvaro Sanabria and Rodrigo, {Juan P} and Alfio Ferlito",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Healthcare Ltd., part of Springer Nature 2024.",

year = "2024",

month = apr,

day = "20",

doi = "10.1007/s12325-024-02861-6",

language = "English",

journal = "Advances in therapy",

issn = "0741-238X",

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Asarkar, AA, Chang, BA, de Bree, R, Kowalski, LP, Guntinas-Lichius, O, Bradley, PJ, de Graaf, P, Strojan, P, Rao, KN, Mäkitie, AA, López, F, Rinaldo, A, Palme, C, Genden, EM, Sanabria, A, Rodrigo, JP & Ferlito, A 2024, 'Primary Management of Operable Locally Advanced Oral Cavity Squamous Cell Carcinoma: Current Concepts and Strategies', Advances in therapy. https://doi.org/10.1007/s12325-024-02861-6

TY - JOUR

T1 - Primary Management of Operable Locally Advanced Oral Cavity Squamous Cell Carcinoma

T2 - Current Concepts and Strategies

AU - Asarkar, Ameya A

AU - Chang, Brent A

AU - de Bree, Remco

AU - Kowalski, Luiz P

AU - Guntinas-Lichius, Orlando

AU - Bradley, Patrick J

AU - de Graaf, Pim

AU - Strojan, Primož

AU - Rao, Karthik N

AU - Mäkitie, Antti A

AU - López, Fernando

AU - Rinaldo, Alessandra

AU - Palme, Carsten

AU - Genden, Eric M

AU - Sanabria, Alvaro

AU - Rodrigo, Juan P

AU - Ferlito, Alfio

N1 - Publisher Copyright: © The Author(s), under exclusive licence to Springer Healthcare Ltd., part of Springer Nature 2024.

PY - 2024/4/20

Y1 - 2024/4/20

N2 - INTRODUCTION: Locally advanced oral cavity carcinoma (LAOCSCC) is primarily treated with surgery followed by radiotherapy with or without chemotherapy.METHODS: A review of literature using PubMED was performed for studies reporting the management of LAOCSCC. Based on the reviewed literature and opinions of experts in the field, recommendations were made.RESULTS: Studies have shown that outcomes following resection of T4a and infranotch (inferior to mandibular notch) T4b are comparable. We discuss the concept of compartmental resection of LAOCSCC and issues concerning the management of the neck. Further, patients who refuse or are unable to undergo surgery can be treated with chemoradiotherapy with uncertain outcomes. The role of neoadjuvant chemotherapy has shown promise for organ (mandibular) preservation in a select subset of patients.CONCLUSION: The management strategy for LAOCSCC should be determined in a multidisciplinary setting with emphasis on tumor control, functional preservation, and quality of life of the patient.

AB - INTRODUCTION: Locally advanced oral cavity carcinoma (LAOCSCC) is primarily treated with surgery followed by radiotherapy with or without chemotherapy.METHODS: A review of literature using PubMED was performed for studies reporting the management of LAOCSCC. Based on the reviewed literature and opinions of experts in the field, recommendations were made.RESULTS: Studies have shown that outcomes following resection of T4a and infranotch (inferior to mandibular notch) T4b are comparable. We discuss the concept of compartmental resection of LAOCSCC and issues concerning the management of the neck. Further, patients who refuse or are unable to undergo surgery can be treated with chemoradiotherapy with uncertain outcomes. The role of neoadjuvant chemotherapy has shown promise for organ (mandibular) preservation in a select subset of patients.CONCLUSION: The management strategy for LAOCSCC should be determined in a multidisciplinary setting with emphasis on tumor control, functional preservation, and quality of life of the patient.

KW - Margins

KW - Neoadjuvant chemotherapy, surgery

KW - Oral cavity squamous cell carcinoma

KW - TNM

UR - http://www.scopus.com/inward/record.url?scp=85190826881&partnerID=8YFLogxK

U2 - 10.1007/s12325-024-02861-6

DO - 10.1007/s12325-024-02861-6

M3 - Review article

C2 - 38642199

SN - 0741-238X

JO - Advances in therapy

JF - Advances in therapy

ER -

Primary Management of Operable Locally Advanced Oral Cavity Squamous Cell Carcinoma: Current Concepts and Strategies

Abstract

Keywords

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