Primary screening by human papillomavirus testing: Development, implementation, and perspectives

Chris J.L.M. Meijer, J. Cuzick, W. W. Kremer, D. A.M. Heideman, G. Ronco

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


With the discovery that human papillomavirus (HPV) is the leading cause of cervical cancer development, it soon became clear that screening by HPV testing is much more sensitive, reproductive, and objective, but less specific for cervical cancer screening than cytology. To compensate for the lower specificity, triage tests for HPV positive women are needed. In this chapter we discuss the original studies underlining the evidence for the introduction of HPV-based screening. We highlight different collection techniques of cervicovaginal material for HPV and triage testing, including self-sampling, different triage tests to select HPV positive women for colposcopy referral, and describe developments, which may result into full molecular self-screening. Finally the implementation of HPV-based screening in some Western countries is highlighted.

Original languageEnglish
Title of host publicationHuman Papillomavirus
Subtitle of host publicationProving and Using a Viral Cause for Cancer
Number of pages24
ISBN (Electronic)9780128144572
ISBN (Print)9780128144862
Publication statusPublished - 1 Jan 2019


  • Cervical cancer
  • Cervical intraepithelial neoplasia (CIN)
  • Human papillomavirus
  • Screening

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