Abstract
In unilaterally 6-hydroxydopamine-lesioned rats, potentiation of D1-agonist-induced turning behavior by priming with l-DOPA was correlated with changes in striatal neuropeptide mRNA levels. In non-primed rats, administration of the D1-agonist SKF-38393 markedly increased dynorphin and substance P mRNA levels in the lesioned striatum. Priming with l-DOPA dissociated the response of the two neuropeptides to the D1-agonist, with higher dynorphin and reduced substance P mRNA levels.
Original language | English |
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Pages (from-to) | 219-23 |
Number of pages | 5 |
Journal | Experimental Brain Research |
Volume | 61 |
Issue number | 1-2 |
Publication status | Published - 30 Oct 1998 |
Keywords
- 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
- Animals
- Brain
- Corpus Striatum
- Dynorphins
- Injections, Intraperitoneal
- Injections, Subcutaneous
- Journal Article
- Levodopa
- Male
- Oxidopamine
- RNA, Messenger
- Rats
- Rats, Wistar
- Receptors, Dopamine D1
- Research Support, Non-U.S. Gov't
- Stereotaxic Techniques
- Substance P