TY - JOUR
T1 - Prognostic accuracy of factors associated with poor outcome in prenatally diagnosed sacrococcygeal teratoma
T2 - A systematic review and meta-analysis
AU - van Heurn, Lieke J.
AU - Coumans, Audrey
AU - Haak, Monique C.
AU - van der Kaaij, Annemarth
AU - van Heurn, L. W. Ernest
AU - Pajkrt, Eva
AU - Derikx, Joep P. M.
N1 - Funding Information: The authors would like to thank J. W. Schoones for his contribution regarding the execution and updating of the search strategy. Publisher Copyright: © 2023 The Authors. Prenatal Diagnosis published by John Wiley & Sons Ltd.
PY - 2023/11/1
Y1 - 2023/11/1
N2 - Several factors associated with poor outcome in patients with prenatally diagnosed sacrococcygeal teratoma (SCT) have been found. However, the prognostic accuracy of these factors has not been well established. Therefore, we aimed to systematically review the prognostic accuracy of factors associated with poor outcome in these patients. We queried Search Premier, COCHRANE Library, EMCARE, EMBASE, PubMed, ScienceDirect, and Web of Science databases to identify studies regarding patients with prenatally diagnosed SCT. Poor outcome was defined as termination of pregnancy (TOP), intrauterine fetal death (IUFD), or perinatal death. We estimated the odds ratio of factors associated with poor outcome. Eleven studies (447 patients) were included. Overall mortality, including TOP, was 34.9%. Factors associated with poor outcome in fetuses with prenatally diagnosed SCT were cardiomegaly, hypervascular tumor, solid tumor morphology, fetal hydrops, and placentomegaly. A tumor volume to fetal weight ratio (TFR) of >0.12 before a gestational age of 24 weeks is predictive of poor outcome. The prognostic accuracy of factors associated with poor outcome in fetuses prenatally diagnosed with SCT seems promising. Factors associated with cardiac failure such as cardiomegaly, hypervascular tumor, solid tumor morphology, fetal hydrops, placentomegaly, and TFR >0.12 were found to be predictive of poor outcome.
AB - Several factors associated with poor outcome in patients with prenatally diagnosed sacrococcygeal teratoma (SCT) have been found. However, the prognostic accuracy of these factors has not been well established. Therefore, we aimed to systematically review the prognostic accuracy of factors associated with poor outcome in these patients. We queried Search Premier, COCHRANE Library, EMCARE, EMBASE, PubMed, ScienceDirect, and Web of Science databases to identify studies regarding patients with prenatally diagnosed SCT. Poor outcome was defined as termination of pregnancy (TOP), intrauterine fetal death (IUFD), or perinatal death. We estimated the odds ratio of factors associated with poor outcome. Eleven studies (447 patients) were included. Overall mortality, including TOP, was 34.9%. Factors associated with poor outcome in fetuses with prenatally diagnosed SCT were cardiomegaly, hypervascular tumor, solid tumor morphology, fetal hydrops, and placentomegaly. A tumor volume to fetal weight ratio (TFR) of >0.12 before a gestational age of 24 weeks is predictive of poor outcome. The prognostic accuracy of factors associated with poor outcome in fetuses prenatally diagnosed with SCT seems promising. Factors associated with cardiac failure such as cardiomegaly, hypervascular tumor, solid tumor morphology, fetal hydrops, placentomegaly, and TFR >0.12 were found to be predictive of poor outcome.
UR - http://www.scopus.com/inward/record.url?scp=85176922086&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/pd.6457
DO - https://doi.org/10.1002/pd.6457
M3 - Review article
C2 - 37964422
SN - 0197-3851
VL - 43
SP - 1495
EP - 1505
JO - Prenatal diagnosis
JF - Prenatal diagnosis
IS - 12
ER -