TY - JOUR
T1 - Prognostic factors for hereditary cancer distress six months after BRCA1/2 or HNPCC genetic susceptibility testing
AU - van Oostrom, Iris
AU - Meijers-Heijboer, Hanne
AU - Duivenvoorden, Hugo J.
AU - Bröcker-Vriends, Annette H. J. T.
AU - van Asperen, Christi J.
AU - Sijmons, Rolf H.
AU - Seynaeve, Caroline
AU - van Gool, Arthur R.
AU - Klijn, Jan G. M.
AU - Tibben, Aad
PY - 2007
Y1 - 2007
N2 - This study explored predictors for hereditary cancer distress six months after genetic susceptibility testing for a known familial BRCA1/2 or HNPCC related mutation, in order to gain insight into aspects relevant for the identification of individuals needing additional psychosocial support. Coping, illness representations, experiences with cancer in relatives and family system characteristics were assessed in 271 applicants for genetic testing before result disclosure. Hereditary cancer distress was assessed prospectively up to six months after disclosure. Regression analysis revealed that the pretest level of distress, complicated grief, the number of affected first-degree relatives and strong emotional illness representations were factors that best explained hereditary cancer distress. Other significant predictors were illness coherence, passive coping, distraction seeking, being aged <13 years when a parent was affected by cancer and family communication. Individuals who may benefit from additional support may be identified before result disclosure using a short instrument assessing the relevant aspects
AB - This study explored predictors for hereditary cancer distress six months after genetic susceptibility testing for a known familial BRCA1/2 or HNPCC related mutation, in order to gain insight into aspects relevant for the identification of individuals needing additional psychosocial support. Coping, illness representations, experiences with cancer in relatives and family system characteristics were assessed in 271 applicants for genetic testing before result disclosure. Hereditary cancer distress was assessed prospectively up to six months after disclosure. Regression analysis revealed that the pretest level of distress, complicated grief, the number of affected first-degree relatives and strong emotional illness representations were factors that best explained hereditary cancer distress. Other significant predictors were illness coherence, passive coping, distraction seeking, being aged <13 years when a parent was affected by cancer and family communication. Individuals who may benefit from additional support may be identified before result disclosure using a short instrument assessing the relevant aspects
U2 - https://doi.org/10.1016/j.ejca.2006.08.023
DO - https://doi.org/10.1016/j.ejca.2006.08.023
M3 - Article
C2 - 17045473
SN - 0959-8049
VL - 43
SP - 71
EP - 77
JO - European journal of cancer (Oxford, England
JF - European journal of cancer (Oxford, England
IS - 1
ER -