TY - JOUR
T1 - Prognostic relevance of PCI-related myocardial infarction
AU - Woudstra, Pier
AU - Grundeken, Maik J.
AU - van de Hoef, Tim P.
AU - Wallentin, Lars
AU - Fox, Keith A.
AU - de Winter, Robbert J.
AU - Damman, Peter
PY - 2013
Y1 - 2013
N2 - Procedure-related myocardial infarction (pMI) is directly associated with a coronary revascularization procedure, such as percutaneous coronary intervention (PCI) or CABG surgery. In contrast to spontaneous myocardial infarction (MI), the prognostic relevance of pMI is the subject of ongoing debate. Data from retrospective analyses of large, randomized clinical trials, and large, contemporary cohort studies have several shortcomings that limit their extrapolation to clinical practice. In our opinion, the currently available evidence is insufficient to conclude that pMI during PCI, as currently defined, always has important prognostic implications. Until further evidence is available, we recommend adopting the definition for MI given in the third universal definition of MI, which differentiates between pMI and spontaneous MI. This is important not only for clinical decision-making but also for the interpretation of pMI as a surrogate end point in clinical trials. Further studies are essential to understand the pathophysiology and consequences of pMI
AB - Procedure-related myocardial infarction (pMI) is directly associated with a coronary revascularization procedure, such as percutaneous coronary intervention (PCI) or CABG surgery. In contrast to spontaneous myocardial infarction (MI), the prognostic relevance of pMI is the subject of ongoing debate. Data from retrospective analyses of large, randomized clinical trials, and large, contemporary cohort studies have several shortcomings that limit their extrapolation to clinical practice. In our opinion, the currently available evidence is insufficient to conclude that pMI during PCI, as currently defined, always has important prognostic implications. Until further evidence is available, we recommend adopting the definition for MI given in the third universal definition of MI, which differentiates between pMI and spontaneous MI. This is important not only for clinical decision-making but also for the interpretation of pMI as a surrogate end point in clinical trials. Further studies are essential to understand the pathophysiology and consequences of pMI
U2 - https://doi.org/10.1038/nrcardio.2013.19
DO - https://doi.org/10.1038/nrcardio.2013.19
M3 - Article
C2 - 23438686
SN - 1759-5002
VL - 10
SP - 231
EP - 236
JO - Nature Reviews. Cardiology
JF - Nature Reviews. Cardiology
IS - 4
ER -