Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension

Serge A van Wolferen; Johannes T Marcus; Anco Boonstra; Koen M J Marques; Jean G F Bronzwaer; Marieke D Spreeuwenberg; Pieter E Postmus; Anton Vonk-Noordegraaf

doi:https://doi.org/10.1093/eurheartj/ehl477

Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension

Serge A van Wolferen, Johannes T Marcus, Anco Boonstra, Koen M J Marques, Jean G F Bronzwaer, Marieke D Spreeuwenberg, Pieter E Postmus, Anton Vonk-Noordegraaf

Research output: Contribution to journal › Article › Academic › peer-review

629 Citations (Scopus)

Abstract

AIMS: This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH).

METHODS AND RESULTS: In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at baseline and after 1-year follow-up. RV structure and function were analysed as predictors of mortality. During a mean follow-up of 32 months, 19 patients died. A low stroke volume (SV), RV dilatation, and impaired left ventricular (LV) filling independently predicted mortality. In addition, a further decrease in SV, progressive RV dilatation, and further decrease in LV end-diastolic volume (LVEDV) at 1-year follow-up were the strongest predictors of mortality. According to Kaplan-Meier survival curves, survival was lower in patients with an inframedian SV index <or= 25 mL/m(2), a supramedian RV end-diastolic volume index >or= 84 mL/m(2), and an inframedian LVEDV<or=40 mL/m(2).

CONCLUSIONS: The RV contains prognostic information in IPAH. A large RV volume, low SV, and a reduced LV volume are strong independent predictors of mortality and treatment failure.

Original language	English
Pages (from-to)	1250-7
Number of pages	8
Journal	European Heart journal
Volume	28
Issue number	10
DOIs	https://doi.org/10.1093/eurheartj/ehl477
Publication status	Published - May 2007

Keywords

Adult
Cardiac Catheterization
Exercise Test
Female
Follow-Up Studies
Heart Ventricles/physiopathology
Humans
Hypertension, Pulmonary/diagnosis
Magnetic Resonance Imaging, Cine
Male
Prognosis
Pulmonary Artery/physiopathology
Risk Factors
Stroke Volume
Survival Analysis
Ventricular Dysfunction, Left/diagnosis
Ventricular Dysfunction, Right/diagnosis

Access to Document

https://doi.org/10.1093/eurheartj/ehl477

Cite this

@article{1d6174c13faf494d962d0070de1ee581,

title = "Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension",

abstract = "AIMS: This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH).METHODS AND RESULTS: In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at baseline and after 1-year follow-up. RV structure and function were analysed as predictors of mortality. During a mean follow-up of 32 months, 19 patients died. A low stroke volume (SV), RV dilatation, and impaired left ventricular (LV) filling independently predicted mortality. In addition, a further decrease in SV, progressive RV dilatation, and further decrease in LV end-diastolic volume (LVEDV) at 1-year follow-up were the strongest predictors of mortality. According to Kaplan-Meier survival curves, survival was lower in patients with an inframedian SV index or= 84 mL/m(2), and an inframedian LVEDVCONCLUSIONS: The RV contains prognostic information in IPAH. A large RV volume, low SV, and a reduced LV volume are strong independent predictors of mortality and treatment failure.",

keywords = "Adult, Cardiac Catheterization, Exercise Test, Female, Follow-Up Studies, Heart Ventricles/physiopathology, Humans, Hypertension, Pulmonary/diagnosis, Magnetic Resonance Imaging, Cine, Male, Prognosis, Pulmonary Artery/physiopathology, Risk Factors, Stroke Volume, Survival Analysis, Ventricular Dysfunction, Left/diagnosis, Ventricular Dysfunction, Right/diagnosis",

author = "{van Wolferen}, {Serge A} and Marcus, {Johannes T} and Anco Boonstra and Marques, {Koen M J} and Bronzwaer, {Jean G F} and Spreeuwenberg, {Marieke D} and Postmus, {Pieter E} and Anton Vonk-Noordegraaf",

year = "2007",

month = may,

doi = "https://doi.org/10.1093/eurheartj/ehl477",

language = "English",

volume = "28",

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journal = "European Heart journal",

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publisher = "Oxford University Press",

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T1 - Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension

AU - van Wolferen, Serge A

AU - Marcus, Johannes T

AU - Boonstra, Anco

AU - Marques, Koen M J

AU - Bronzwaer, Jean G F

AU - Spreeuwenberg, Marieke D

AU - Postmus, Pieter E

AU - Vonk-Noordegraaf, Anton

PY - 2007/5

Y1 - 2007/5

N2 - AIMS: This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH).METHODS AND RESULTS: In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at baseline and after 1-year follow-up. RV structure and function were analysed as predictors of mortality. During a mean follow-up of 32 months, 19 patients died. A low stroke volume (SV), RV dilatation, and impaired left ventricular (LV) filling independently predicted mortality. In addition, a further decrease in SV, progressive RV dilatation, and further decrease in LV end-diastolic volume (LVEDV) at 1-year follow-up were the strongest predictors of mortality. According to Kaplan-Meier survival curves, survival was lower in patients with an inframedian SV index or= 84 mL/m(2), and an inframedian LVEDVCONCLUSIONS: The RV contains prognostic information in IPAH. A large RV volume, low SV, and a reduced LV volume are strong independent predictors of mortality and treatment failure.

AB - AIMS: This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH).METHODS AND RESULTS: In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at baseline and after 1-year follow-up. RV structure and function were analysed as predictors of mortality. During a mean follow-up of 32 months, 19 patients died. A low stroke volume (SV), RV dilatation, and impaired left ventricular (LV) filling independently predicted mortality. In addition, a further decrease in SV, progressive RV dilatation, and further decrease in LV end-diastolic volume (LVEDV) at 1-year follow-up were the strongest predictors of mortality. According to Kaplan-Meier survival curves, survival was lower in patients with an inframedian SV index or= 84 mL/m(2), and an inframedian LVEDVCONCLUSIONS: The RV contains prognostic information in IPAH. A large RV volume, low SV, and a reduced LV volume are strong independent predictors of mortality and treatment failure.

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KW - Hypertension, Pulmonary/diagnosis

KW - Magnetic Resonance Imaging, Cine

KW - Male

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KW - Pulmonary Artery/physiopathology

KW - Risk Factors

KW - Stroke Volume

KW - Survival Analysis

KW - Ventricular Dysfunction, Left/diagnosis

KW - Ventricular Dysfunction, Right/diagnosis

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DO - https://doi.org/10.1093/eurheartj/ehl477

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JO - European Heart journal

JF - European Heart journal

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