TY - JOUR
T1 - Progress against childhood and adolescent acute lymphoblastic leukaemia in the Netherlands, 1990–2015
AU - Reedijk, Ardine M. J.
AU - Coebergh, Jan Willem W.
AU - de Groot-Kruseman, Hester A.
AU - van der Sluis, Inge M.
AU - Kremer, Leontien C.
AU - Karim-Kos, Henrike E.
AU - Pieters, Rob
N1 - Funding Information: Acknowledgements The current work is funded by Stichting Kinderen Kankervrij (KiKa) [project number 207]. The funding source had no role in the study design, data collection, analyses and interpretation of the results, nor in writing of this manuscript. We thank the registration team of the Netherlands Comprehensive Cancer Organization (IKNL) for the collection of data for the Netherlands Cancer Registry. We thank Dr. Otto Visser (IKNL) for the extra data checks for the current study. We thank the laboratory personnel and the data managers from the Dutch Childhood Oncology Group (DCOG) for collecting the data for the DCOG registry. We recognise all paediatric oncologists who treated the patients and provided data in the DCLSG/DCOG collaboration. Publisher Copyright: © 2020, The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/4
Y1 - 2021/4
N2 - We assessed the epidemiologic progress against childhood and adolescent acute lymphoblastic leukaemia (ALL) in the Netherlands over a 26 year period. ALL patients <18 years were selected from the Netherlands Cancer Registry and the Dutch Childhood Oncology Group. Trend analyses were performed over time and by age group and ALL subtype. Between 1990 and 2015, 2997 ALL patients were diagnosed, i.e. 115 patients (range 87–147) per year. Overall incidence remained stable at 37 per million children, despite increases for B-cell precursor ALL (BCP-ALL) at age 10–14 years (AAPC + 1.4%, p = 0.04) and T-cell ALL at 15–17 years (AAPC + 3.7%, p = 0.01). Five-year survival increased from 80% in 1990–94 to 91% in 2010–15 (p < 0.01). Mortality decreased by 4% annually (p < 0.01). Patients 15–17 years were increasingly treated in a paediatric oncology centre, from 35% in 1990–94 to 87% in 2010–15 and experienced a 70% reduction of risk of death compared to those treated outside such a centre (p < 0.01). Significant progress against childhood ALL has been made in the Netherlands, visible by improved survival rates coinciding with declining mortality rates. These outcomes were accompanied by stable incidence rates, despite increases for BCP-ALL at age 10–14 years and T-cell ALL at age 15–17 years.
AB - We assessed the epidemiologic progress against childhood and adolescent acute lymphoblastic leukaemia (ALL) in the Netherlands over a 26 year period. ALL patients <18 years were selected from the Netherlands Cancer Registry and the Dutch Childhood Oncology Group. Trend analyses were performed over time and by age group and ALL subtype. Between 1990 and 2015, 2997 ALL patients were diagnosed, i.e. 115 patients (range 87–147) per year. Overall incidence remained stable at 37 per million children, despite increases for B-cell precursor ALL (BCP-ALL) at age 10–14 years (AAPC + 1.4%, p = 0.04) and T-cell ALL at 15–17 years (AAPC + 3.7%, p = 0.01). Five-year survival increased from 80% in 1990–94 to 91% in 2010–15 (p < 0.01). Mortality decreased by 4% annually (p < 0.01). Patients 15–17 years were increasingly treated in a paediatric oncology centre, from 35% in 1990–94 to 87% in 2010–15 and experienced a 70% reduction of risk of death compared to those treated outside such a centre (p < 0.01). Significant progress against childhood ALL has been made in the Netherlands, visible by improved survival rates coinciding with declining mortality rates. These outcomes were accompanied by stable incidence rates, despite increases for BCP-ALL at age 10–14 years and T-cell ALL at age 15–17 years.
UR - http://www.scopus.com/inward/record.url?scp=85089658886&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41375-020-01024-0
DO - https://doi.org/10.1038/s41375-020-01024-0
M3 - Article
C2 - 32820270
SN - 0887-6924
VL - 35
SP - 1001
EP - 1011
JO - Leukemia
JF - Leukemia
IS - 4
ER -