TY - JOUR
T1 - Prospects for future studies in head and neck cancer
AU - Van Dongen, Guus A.M.S.
AU - Snow, Gordon B.
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Present therapy of head and neck cancer patients includes surgical procedures, radiotherapy and sometimes chemotherapy. Over recent decades no dramatic improvements have been obtained with these treatment modalities with respect to efficacy and associated morbidity. Of patients with early stage disease (stage I and II), about 25% cannot be cured, while for patients with advanced disease (stage III and IV) this percentage may be as high as 70%. However, owing to advances in our knowledge of molecular biology, immunology, (bio)chemistry and biology of head and neck squamous cell carcinoma (HNSCC), new perspectives on therapy are arising. After several years of optimization several new therapeutic approaches are leaving their infancy and are being evaluated in clinical trials with HNSCC patients. Among other approaches, photodynamic therapy, gene therapy and antibody-based therapy are attracting most attention. The basic concepts and the potential applications of these treatment modalities in the management of head and neck cancer are discussed in this paper.
AB - Present therapy of head and neck cancer patients includes surgical procedures, radiotherapy and sometimes chemotherapy. Over recent decades no dramatic improvements have been obtained with these treatment modalities with respect to efficacy and associated morbidity. Of patients with early stage disease (stage I and II), about 25% cannot be cured, while for patients with advanced disease (stage III and IV) this percentage may be as high as 70%. However, owing to advances in our knowledge of molecular biology, immunology, (bio)chemistry and biology of head and neck squamous cell carcinoma (HNSCC), new perspectives on therapy are arising. After several years of optimization several new therapeutic approaches are leaving their infancy and are being evaluated in clinical trials with HNSCC patients. Among other approaches, photodynamic therapy, gene therapy and antibody-based therapy are attracting most attention. The basic concepts and the potential applications of these treatment modalities in the management of head and neck cancer are discussed in this paper.
KW - Antibody-based therapy
KW - Gene therapy
KW - Head and neck cancer
KW - Photodynamic therapy
UR - http://www.scopus.com/inward/record.url?scp=0031471650&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/S0748-7983(97)92789-X
DO - https://doi.org/10.1016/S0748-7983(97)92789-X
M3 - Article
C2 - 9484916
SN - 0748-7983
VL - 23
SP - 486
EP - 491
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
IS - 6
ER -