TY - CHAP
T1 - Protein Metabolism and Requirement in Intensive Care Units and Septic Patients
AU - Weijs, P. J. M.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Amino acid and protein metabolism are dramatically affected in critically ill patients, and especially when admitted to the Intensive Care Unit (ICU) with sepsis. How important nutrition is in the early phase of ICU stay is highly debated. Moreover, it is important to realize that protein metabolism and nutrition in ICU has been chronically understudied. Questions about when to give how much protein cannot be supported by amino acid (AA) level evidence. What can we learn from randomized controlled nutrition studies in the ICU? Descriptive studies have repeatedly shown a positive relationship between protein feeding at the current guideline level of 1.2 g/kg/d and outcome as hospital mortality. However, this high level of protein intake requires targeted feeding, which also increases the risks of energy overfeeding. In order to provide optimal nutrition to critically ill patients we need higher protein formulae and outcome studies considering long-term physical function after ICU stay.
AB - Amino acid and protein metabolism are dramatically affected in critically ill patients, and especially when admitted to the Intensive Care Unit (ICU) with sepsis. How important nutrition is in the early phase of ICU stay is highly debated. Moreover, it is important to realize that protein metabolism and nutrition in ICU has been chronically understudied. Questions about when to give how much protein cannot be supported by amino acid (AA) level evidence. What can we learn from randomized controlled nutrition studies in the ICU? Descriptive studies have repeatedly shown a positive relationship between protein feeding at the current guideline level of 1.2 g/kg/d and outcome as hospital mortality. However, this high level of protein intake requires targeted feeding, which also increases the risks of energy overfeeding. In order to provide optimal nutrition to critically ill patients we need higher protein formulae and outcome studies considering long-term physical function after ICU stay.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85134451329&origin=inward
U2 - https://doi.org/10.1016/B978-0-12-802167-5.00010-4
DO - https://doi.org/10.1016/B978-0-12-802167-5.00010-4
M3 - Chapter
SN - 9780128023754
T3 - The Molecular Nutrition of Amino Acids and Proteins: A Volume in the Molecular Nutrition Series
SP - 125
EP - 132
BT - The Molecular Nutrition of Amino Acids and Proteins: A Volume in the Molecular Nutrition Series
PB - Elsevier
ER -