Proximal embolic protection with aspiration in percutaneous coronary intervention using the Proxis device

Karel T. Koch; Joost D. E. Haeck; René J. van der Schaaf; Frazil M. Alidjan; José P. S. Henriques; Jan Baan; Jan J. Piek; Allard C. van der Wal; Jan G. P. Tijssen; Gabor Sütsch; Robbert J. de Winter

Proximal embolic protection with aspiration in percutaneous coronary intervention using the Proxis device

Karel T. Koch, Joost D. E. Haeck, René J. van der Schaaf, Frazil M. Alidjan, José P. S. Henriques, Jan Baan, Jan J. Piek, Allard C. van der Wal, Jan G. P. Tijssen, Gabor Sütsch, Robbert J. de Winter

Research output: Contribution to journal › Review article › Academic › peer-review

15 Citations (Scopus)

Abstract

Distal embolization during primary percutaneous coronary intervention (PCI) occurs in at least 15% of patients and is a strong predictor of more extensive myocardial damage and a poor prognosis. Several devices are designed to evacuate the intracoronary thrombus or to prevent distal embolization. The Proxis device is a proximal embolic protection system that completely blocks antegrade flow during PCI. It may prevent distal embolization during recanalization of thrombotic coronary occlusion and thus improve outcome. We created a registry of 172 patients with ST-segment elevation myocardial infarction who underwent primary PCI with proximal embolic protection and aspiration. The mean ST-segment elevation resolution (STR) at 1 hour was 77.7%+/- 15.2; STR was greater than 50% in 94% and greater than 70% in 72% of patients. The 1-year cumulative major adverse cardiac and cerebrovascular events rate was 10.5%. The overall mortality at 1 year was 2.3%

Original language	English
Pages (from-to)	160-166
Journal	Reviews in cardiovascular medicine
Volume	8
Issue number	3
Publication status	Published - 2007

Cite this

@article{0741a737c16a4b42b95d33056fbca07e,

title = "Proximal embolic protection with aspiration in percutaneous coronary intervention using the Proxis device",

abstract = "Distal embolization during primary percutaneous coronary intervention (PCI) occurs in at least 15% of patients and is a strong predictor of more extensive myocardial damage and a poor prognosis. Several devices are designed to evacuate the intracoronary thrombus or to prevent distal embolization. The Proxis device is a proximal embolic protection system that completely blocks antegrade flow during PCI. It may prevent distal embolization during recanalization of thrombotic coronary occlusion and thus improve outcome. We created a registry of 172 patients with ST-segment elevation myocardial infarction who underwent primary PCI with proximal embolic protection and aspiration. The mean ST-segment elevation resolution (STR) at 1 hour was 77.7%+/- 15.2; STR was greater than 50% in 94% and greater than 70% in 72% of patients. The 1-year cumulative major adverse cardiac and cerebrovascular events rate was 10.5%. The overall mortality at 1 year was 2.3%",

author = "Koch, {Karel T.} and Haeck, {Joost D. E.} and {van der Schaaf}, {Ren{\'e} J.} and Alidjan, {Frazil M.} and Henriques, {Jos{\'e} P. S.} and Jan Baan and Piek, {Jan J.} and {van der Wal}, {Allard C.} and Tijssen, {Jan G. P.} and Gabor S{\"u}tsch and {de Winter}, {Robbert J.}",

year = "2007",

language = "English",

volume = "8",

pages = "160--166",

journal = "Reviews in cardiovascular medicine",

issn = "1530-6550",

publisher = "IMR Press Limited",

number = "3",

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TY - JOUR

T1 - Proximal embolic protection with aspiration in percutaneous coronary intervention using the Proxis device

AU - Koch, Karel T.

AU - Haeck, Joost D. E.

AU - van der Schaaf, René J.

AU - Alidjan, Frazil M.

AU - Henriques, José P. S.

AU - Baan, Jan

AU - Piek, Jan J.

AU - van der Wal, Allard C.

AU - Tijssen, Jan G. P.

AU - Sütsch, Gabor

AU - de Winter, Robbert J.

PY - 2007

Y1 - 2007

N2 - Distal embolization during primary percutaneous coronary intervention (PCI) occurs in at least 15% of patients and is a strong predictor of more extensive myocardial damage and a poor prognosis. Several devices are designed to evacuate the intracoronary thrombus or to prevent distal embolization. The Proxis device is a proximal embolic protection system that completely blocks antegrade flow during PCI. It may prevent distal embolization during recanalization of thrombotic coronary occlusion and thus improve outcome. We created a registry of 172 patients with ST-segment elevation myocardial infarction who underwent primary PCI with proximal embolic protection and aspiration. The mean ST-segment elevation resolution (STR) at 1 hour was 77.7%+/- 15.2; STR was greater than 50% in 94% and greater than 70% in 72% of patients. The 1-year cumulative major adverse cardiac and cerebrovascular events rate was 10.5%. The overall mortality at 1 year was 2.3%

AB - Distal embolization during primary percutaneous coronary intervention (PCI) occurs in at least 15% of patients and is a strong predictor of more extensive myocardial damage and a poor prognosis. Several devices are designed to evacuate the intracoronary thrombus or to prevent distal embolization. The Proxis device is a proximal embolic protection system that completely blocks antegrade flow during PCI. It may prevent distal embolization during recanalization of thrombotic coronary occlusion and thus improve outcome. We created a registry of 172 patients with ST-segment elevation myocardial infarction who underwent primary PCI with proximal embolic protection and aspiration. The mean ST-segment elevation resolution (STR) at 1 hour was 77.7%+/- 15.2; STR was greater than 50% in 94% and greater than 70% in 72% of patients. The 1-year cumulative major adverse cardiac and cerebrovascular events rate was 10.5%. The overall mortality at 1 year was 2.3%

M3 - Review article

C2 - 17938616

SN - 1530-6550

VL - 8

SP - 160

EP - 166

JO - Reviews in cardiovascular medicine

JF - Reviews in cardiovascular medicine

IS - 3

ER -