TY - JOUR
T1 - Psoralen and long wavelength ultraviolet radiation as an adjuvant therapy for prevention of intimal hyperplasia and constrictive remodeling after balloon dilation: a study in the rabbit iliac artery
AU - Perrée, J.
AU - van Leeuwen, T. G.
AU - Velema, E.
AU - Borst, C.
PY - 1998
Y1 - 1998
N2 - BACKGROUND AND OBJECTIVE: Restenosis after balloon angioplasty is the summated effect of intimal hyperplasia and arterial shrinkage, both caused by hyperproliferation. In the present study, the potential of a photochemotherapeutic modality (Psoralen + UVA: PUVA) for the prevention of angioplasty induced proliferation was explored. STUDY DESIGN/MATERIALS AND METHODS: In rabbit iliac arteries, balloon dilation followed by PUVA-therapy (H = 1 J/cm2) was performed (n = 15). Contralateral arteries served as control. After 2 and 28 days of survival, the contribution of intimal hyperplasia and remodeling to lumen loss was determined by means of angiography and histological analysis. RESULTS: After 2 days, large parts of the media had become acellular, while proliferation was occurring predominantly in the adventitia in both groups. After 28 days, late loss, arterial shrinkage, but not intimal hyperplasia were larger in the PUVA group (P <0.05). CONCLUSION: PUVA-therapy did not prevent intimal hyperplasia following balloon dilation but enhanced luminal narrowing by augmented constrictive remodeling
AB - BACKGROUND AND OBJECTIVE: Restenosis after balloon angioplasty is the summated effect of intimal hyperplasia and arterial shrinkage, both caused by hyperproliferation. In the present study, the potential of a photochemotherapeutic modality (Psoralen + UVA: PUVA) for the prevention of angioplasty induced proliferation was explored. STUDY DESIGN/MATERIALS AND METHODS: In rabbit iliac arteries, balloon dilation followed by PUVA-therapy (H = 1 J/cm2) was performed (n = 15). Contralateral arteries served as control. After 2 and 28 days of survival, the contribution of intimal hyperplasia and remodeling to lumen loss was determined by means of angiography and histological analysis. RESULTS: After 2 days, large parts of the media had become acellular, while proliferation was occurring predominantly in the adventitia in both groups. After 28 days, late loss, arterial shrinkage, but not intimal hyperplasia were larger in the PUVA group (P <0.05). CONCLUSION: PUVA-therapy did not prevent intimal hyperplasia following balloon dilation but enhanced luminal narrowing by augmented constrictive remodeling
U2 - https://doi.org/10.1002/(SICI)1096-9101(1998)23:5<281::AID-LSM8>3.0.CO;2-T
DO - https://doi.org/10.1002/(SICI)1096-9101(1998)23:5<281::AID-LSM8>3.0.CO;2-T
M3 - Article
C2 - 9888324
SN - 0196-8092
VL - 23
SP - 281
EP - 290
JO - Lasers in surgery and medicine
JF - Lasers in surgery and medicine
IS - 5
ER -