TY - JOUR
T1 - Psychiatric disorders, myoclonus dystonia and SGCE: an international study
AU - Peall, Kathryn J.
AU - Dijk, Joke M.
AU - Saunders-Pullman, Rachel
AU - Dreissen, Yasmine E. M.
AU - van Loon, Ilke
AU - Cath, Danielle
AU - Kurian, Manju A.
AU - Owen, Michael J.
AU - Foncke, Elisabeth M. J.
AU - Morris, Huw R.
AU - Gasser, Thomas
AU - Bressman, Susan
AU - Asmus, Friedrich
AU - Tijssen, Marina A. J.
PY - 2016
Y1 - 2016
N2 - ObjectiveMyoclonus-dystonia (M-D) is a hyperkinetic movement disorder, typically alcohol-responsive upper body myoclonus and dystonia. The majority of autosomal dominant familial cases are caused by epsilon-sarcoglycan gene (SGCE) mutations. Previous publications have observed increased rates of psychiatric disorders amongst SGCE mutation-positive populations. We analyzed the psychiatric data from four international centers, forming the largest cohort to date, to further determine the extent and type of psychiatric disorders in M-D. MethodsPsychiatric data from SGCE mutation-positive M-D cohorts, collected by movement disorder specialists in the Netherlands, United Kingdom, United States, and Germany, were analyzed. These data were collected using standardized, systematic questionnaires allowing classification of symptoms according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria. Based on motor findings and SGCE mutation analysis, participants were classified into one of three groups: manifesting carriers, nonmanifesting carriers and noncarriers. ResultsData from 307 participants were evaluated (140 males, 167 females, mean age at examination: 42.5 years). Two-thirds of motor affected mutation carriers (n = 132) had 1 psychiatric diagnosis, specific, and social phobias being most common followed by alcohol dependence and obsessive-compulsive disorder (OCD). Compared to familial controls, affected mutation carriers had significantly elevated overall rates of psychiatric disorders (P <0.001). The most significant differences were observed with alcohol dependence (P <0.001), OCD (P <0.001), social and specific phobias (P <0.001). InterpretationM-D due to SGCE mutations is associated with specific psychiatric disorders, most commonly OCD, anxiety-related disorders, and alcohol dependence. These suggest either a potential pleiotropic function for SGCE within the central nervous system or a secondary effect of the motor disorder
AB - ObjectiveMyoclonus-dystonia (M-D) is a hyperkinetic movement disorder, typically alcohol-responsive upper body myoclonus and dystonia. The majority of autosomal dominant familial cases are caused by epsilon-sarcoglycan gene (SGCE) mutations. Previous publications have observed increased rates of psychiatric disorders amongst SGCE mutation-positive populations. We analyzed the psychiatric data from four international centers, forming the largest cohort to date, to further determine the extent and type of psychiatric disorders in M-D. MethodsPsychiatric data from SGCE mutation-positive M-D cohorts, collected by movement disorder specialists in the Netherlands, United Kingdom, United States, and Germany, were analyzed. These data were collected using standardized, systematic questionnaires allowing classification of symptoms according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria. Based on motor findings and SGCE mutation analysis, participants were classified into one of three groups: manifesting carriers, nonmanifesting carriers and noncarriers. ResultsData from 307 participants were evaluated (140 males, 167 females, mean age at examination: 42.5 years). Two-thirds of motor affected mutation carriers (n = 132) had 1 psychiatric diagnosis, specific, and social phobias being most common followed by alcohol dependence and obsessive-compulsive disorder (OCD). Compared to familial controls, affected mutation carriers had significantly elevated overall rates of psychiatric disorders (P <0.001). The most significant differences were observed with alcohol dependence (P <0.001), OCD (P <0.001), social and specific phobias (P <0.001). InterpretationM-D due to SGCE mutations is associated with specific psychiatric disorders, most commonly OCD, anxiety-related disorders, and alcohol dependence. These suggest either a potential pleiotropic function for SGCE within the central nervous system or a secondary effect of the motor disorder
U2 - https://doi.org/10.1002/acn3.263
DO - https://doi.org/10.1002/acn3.263
M3 - Article
C2 - 26783545
SN - 2328-9503
VL - 3
SP - 4
EP - 11
JO - Annals of clinical and translational neurology
JF - Annals of clinical and translational neurology
IS - 1
ER -