TY - JOUR
T1 - Psychological well-being in patients with aneurysms-osteoarthritis syndrome
AU - Bons, L.R.
AU - van den Hoven, A.T.
AU - Damirchi, A.E.
AU - van der Linde, D.
AU - Dekker, S.
AU - Kauling, R.M.
AU - van de Laar, I.M.B.H.
AU - Utens, E.M.W.J.
AU - Budde, R.P.J.
AU - Roos-Hesselink, J.W.
N1 - With supplementary file.
PY - 2019/8
Y1 - 2019/8
N2 - Aneurysms-osteoarthritis syndrome (AOS) is characterized by arterial aneurysms and dissection in combination with early-onset osteoarthritis, which can impact quality of life. We describe the subjective quality of life and investigate anxiety and depression in 28 AOS patients aged 15–73 years. Three questionnaires were used: 36-Item Short Form Survey (SF-36), hospital anxiety and depression scale (HADS) and Rotterdam disease specific questionnaire. Results of the SF-36 and HADS were compared to a reference Dutch cohort and the SF-36 questionnaire also to patients with Marfan syndrome. Compared to the general population, AOS patients scored significantly lower on the following SF-36 domains: physical functioning, vitality, social functioning, bodily pain, and general health. Physical functioning was also lower than in Marfan patients. Patients with AOS scored higher on the HADS depression scale, while anxiety did not show a significant difference compared to the general population. No difference in SF-36 and HADS domain scores were found between patient with and without orthopaedic symptoms and patients with or without previous aortic surgery. Additionally, we found that patients' worries for their future and heredity of their disease are important factors for anxiety, which should be addressed in clinical practice.
AB - Aneurysms-osteoarthritis syndrome (AOS) is characterized by arterial aneurysms and dissection in combination with early-onset osteoarthritis, which can impact quality of life. We describe the subjective quality of life and investigate anxiety and depression in 28 AOS patients aged 15–73 years. Three questionnaires were used: 36-Item Short Form Survey (SF-36), hospital anxiety and depression scale (HADS) and Rotterdam disease specific questionnaire. Results of the SF-36 and HADS were compared to a reference Dutch cohort and the SF-36 questionnaire also to patients with Marfan syndrome. Compared to the general population, AOS patients scored significantly lower on the following SF-36 domains: physical functioning, vitality, social functioning, bodily pain, and general health. Physical functioning was also lower than in Marfan patients. Patients with AOS scored higher on the HADS depression scale, while anxiety did not show a significant difference compared to the general population. No difference in SF-36 and HADS domain scores were found between patient with and without orthopaedic symptoms and patients with or without previous aortic surgery. Additionally, we found that patients' worries for their future and heredity of their disease are important factors for anxiety, which should be addressed in clinical practice.
KW - aneurysms-osteoarthritis syndrome
KW - anxiety
KW - aortic disease
KW - depression
KW - quality of life
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UR - https://pure.uva.nl/ws/files/45695473/ajmga61209_sup_0001_appendixs1.docx
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85069958221&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31132219
U2 - https://doi.org/10.1002/ajmg.a.61209
DO - https://doi.org/10.1002/ajmg.a.61209
M3 - Article
C2 - 31132219
SN - 1552-4825
VL - 179
SP - 1491
EP - 1497
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
IS - 8
ER -