QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies

QUADAS-2 Group

doi:https://doi.org/10.7326/0003-4819-155-8-201110180-00009

QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies

QUADAS-2 Group

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.

Original language	English
Pages (from-to)	529-36
Number of pages	8
Journal	Annals of Internal Medicine
Volume	155
Issue number	8
DOIs	https://doi.org/10.7326/0003-4819-155-8-201110180-00009
Publication status	Published - 18 Oct 2011

Keywords

Bias
Diagnosis
Evidence-Based Medicine
Humans
Patient Selection
Quality Control
Reference Standards
Review Literature as Topic
Surveys and Questionnaires
Time Factors

Access to Document

https://doi.org/10.7326/0003-4819-155-8-201110180-00009

Cite this

@article{1286b9374ad64c7194728f4177bde8c3,

title = "QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies",

abstract = "In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.",

keywords = "Bias, Diagnosis, Evidence-Based Medicine, Humans, Patient Selection, Quality Control, Reference Standards, Review Literature as Topic, Surveys and Questionnaires, Time Factors",

author = "{QUADAS-2 Group} and Whiting, {Penny F} and Rutjes, {Anne W S} and Westwood, {Marie E} and Susan Mallett and Deeks, {Jonathan J} and Reitsma, {Johannes B} and Leeflang, {Mariska M G} and Sterne, {Jonathan A C} and Bossuyt, {Patrick M M}",

year = "2011",

month = oct,

day = "18",

doi = "https://doi.org/10.7326/0003-4819-155-8-201110180-00009",

language = "English",

volume = "155",

pages = "529--36",

journal = "Annals of Internal Medicine",

issn = "0003-4819",

publisher = "American College of Physicians",

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T2 - a revised tool for the quality assessment of diagnostic accuracy studies

AU - QUADAS-2 Group

AU - Whiting, Penny F

AU - Rutjes, Anne W S

AU - Westwood, Marie E

AU - Mallett, Susan

AU - Deeks, Jonathan J

AU - Reitsma, Johannes B

AU - Leeflang, Mariska M G

AU - Sterne, Jonathan A C

AU - Bossuyt, Patrick M M

PY - 2011/10/18

Y1 - 2011/10/18

N2 - In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.

AB - In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.

KW - Bias

KW - Diagnosis

KW - Evidence-Based Medicine

KW - Humans

KW - Patient Selection

KW - Quality Control

KW - Reference Standards

KW - Review Literature as Topic

KW - Surveys and Questionnaires

KW - Time Factors

U2 - https://doi.org/10.7326/0003-4819-155-8-201110180-00009

DO - https://doi.org/10.7326/0003-4819-155-8-201110180-00009

M3 - Article

C2 - 22007046

SN - 0003-4819

VL - 155

SP - 529

EP - 536

JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

IS - 8

ER -