TY - JOUR
T1 - Quality assurance of the EORTC trial 22881/10882: "assessment of the role of the booster dose in breast conserving therapy": the Dummy Run
AU - van Tienhoven, G.
AU - van Bree, N. A. M.
AU - Mijnheer, B. J.
AU - Bartelink, H.
PY - 1991
Y1 - 1991
N2 - The EORTC trial 22881/10882 is a randomised trial with the aim to assess the role of the boost dose in breast conserving therapy in stage I and II breast cancer. In order to detect potential protocol deviations concerning irradiation technique and in the dose specification procedure of participating institutions before actual patient accrual, a Dummy Run was performed. Three transverse sections of a patient were sent to 16 participating institutions with a request to make a three-plane treatment plan according to the protocol prescriptions. A treatment chart and beam data were also requested for recalculation of the dose. Additional information was asked in a questionnaire. On evaluation, the techniques differed considerably with respect to photon beam energy, varying between 60Co gamma-rays and 8 MV X-rays, and the use of wedge filters. Two institutions did not apply wedges, whereas wedge angles in the other institutions varied between 6° and 45°. Twelve institutions used collimator rotation and/or a table wedge to diminish the amount of irradiated lung volume. The dose was specified in a point according to the protocol prescription in 11 institutions and to the 90, 95 or 100% isodose curve in four. Twelve institutions applied lung density corrections during treatment planning, while nine reported problems with their planning system in off axis dose distribution calculation and/or the simulation of collimator rotation. Recalculation of the dose at the isocentre showed agreement within 2% compared with the stated dose. The dose reported in the tumour excision area varied between 93 and 100%. It can be concluded that good accordance and high quality breast irradiation can be achieved by all institutions participating in the trial, provided a few recommendations are followed. The results of this analysis show the necessity and usefulness of a quality assurance programme at the initial phase of a clinical trial. © 1991.
AB - The EORTC trial 22881/10882 is a randomised trial with the aim to assess the role of the boost dose in breast conserving therapy in stage I and II breast cancer. In order to detect potential protocol deviations concerning irradiation technique and in the dose specification procedure of participating institutions before actual patient accrual, a Dummy Run was performed. Three transverse sections of a patient were sent to 16 participating institutions with a request to make a three-plane treatment plan according to the protocol prescriptions. A treatment chart and beam data were also requested for recalculation of the dose. Additional information was asked in a questionnaire. On evaluation, the techniques differed considerably with respect to photon beam energy, varying between 60Co gamma-rays and 8 MV X-rays, and the use of wedge filters. Two institutions did not apply wedges, whereas wedge angles in the other institutions varied between 6° and 45°. Twelve institutions used collimator rotation and/or a table wedge to diminish the amount of irradiated lung volume. The dose was specified in a point according to the protocol prescription in 11 institutions and to the 90, 95 or 100% isodose curve in four. Twelve institutions applied lung density corrections during treatment planning, while nine reported problems with their planning system in off axis dose distribution calculation and/or the simulation of collimator rotation. Recalculation of the dose at the isocentre showed agreement within 2% compared with the stated dose. The dose reported in the tumour excision area varied between 93 and 100%. It can be concluded that good accordance and high quality breast irradiation can be achieved by all institutions participating in the trial, provided a few recommendations are followed. The results of this analysis show the necessity and usefulness of a quality assurance programme at the initial phase of a clinical trial. © 1991.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0026347726&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/1792323
U2 - https://doi.org/10.1016/0167-8140(91)90165-D
DO - https://doi.org/10.1016/0167-8140(91)90165-D
M3 - Article
C2 - 1792323
SN - 0167-8140
VL - 22
SP - 290
EP - 298
JO - Radiotherapy and oncology
JF - Radiotherapy and oncology
IS - 4
ER -