TY - JOUR
T1 - Quality of life after curative or palliative surgical treatment of pancreatic and periampullary carcinoma
AU - Van Dijkum, E. J.M.Nieveein
AU - Kuhlmann, K. F.D.
AU - Terwee, C. B.
AU - Obertop, H.
AU - De Haes, J. C.J.M.
AU - Gouma, D. J.
AU - Nieveen van Dijkum, E. J. M.
PY - 2005/4
Y1 - 2005/4
N2 - Background: Quality of life (QOL) is an important outcome measure after treatment of pancreatic and periampullary carcinoma. The aim of this prospective longitudinal study was to analyse QOL after surgery for resectable pancreatic or periampullary carcinoma. Methods: Patients with potentially resectable tumours underwent pancreaticoduodenectomy (n = 72) or a double-bypass procedure (n = 42). They were asked to complete a questionnaire before laparotomy and at 2 weeks, 6 weeks, and 3, 6, 9 and 12 months after surgery. Fifty-nine patients completed a shortened questionnaire on a weekly basis. Results: There was a temporary decrease in physical and gastrointestinal functioning after pancreaticoduodenectomy. A similar decrease hi QOL was observed after double bypass, as well as decreases in mental functioning and overall QOL. Almost all QOL scores returned to preoperative values by about 3 months after surgery, although only briefly so in patients who had a double-bypass procedure. There were no differences between groups hi the terminal stages of disease. A rapid decrease on all QOL scales was observed in the last 8 weeks before death. Conclusion: Surgery for pancreatic and periampullary carcinoma was not associated with irreversible impairment or protracted recovery of QOL. The relatively long plateau phase after recovery supports the argument for surgical treatment, including surgical palliation in selected patients.
AB - Background: Quality of life (QOL) is an important outcome measure after treatment of pancreatic and periampullary carcinoma. The aim of this prospective longitudinal study was to analyse QOL after surgery for resectable pancreatic or periampullary carcinoma. Methods: Patients with potentially resectable tumours underwent pancreaticoduodenectomy (n = 72) or a double-bypass procedure (n = 42). They were asked to complete a questionnaire before laparotomy and at 2 weeks, 6 weeks, and 3, 6, 9 and 12 months after surgery. Fifty-nine patients completed a shortened questionnaire on a weekly basis. Results: There was a temporary decrease in physical and gastrointestinal functioning after pancreaticoduodenectomy. A similar decrease hi QOL was observed after double bypass, as well as decreases in mental functioning and overall QOL. Almost all QOL scores returned to preoperative values by about 3 months after surgery, although only briefly so in patients who had a double-bypass procedure. There were no differences between groups hi the terminal stages of disease. A rapid decrease on all QOL scales was observed in the last 8 weeks before death. Conclusion: Surgery for pancreatic and periampullary carcinoma was not associated with irreversible impairment or protracted recovery of QOL. The relatively long plateau phase after recovery supports the argument for surgical treatment, including surgical palliation in selected patients.
UR - http://www.scopus.com/inward/record.url?scp=17144380803&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/bjs.4887
DO - https://doi.org/10.1002/bjs.4887
M3 - Article
C2 - 15672431
SN - 0007-1323
VL - 92
SP - 471
EP - 477
JO - British Journal of Surgery
JF - British Journal of Surgery
IS - 4
ER -