TY - JOUR
T1 - Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis
AU - Granziera, Cristina
AU - Wuerfel, Jens
AU - Barkhof, Frederik
AU - Calabrese, Massimiliano
AU - de Stefano, Nicola
AU - Enzinger, Christian
AU - Evangelou, Nikos
AU - Filippi, Massimo
AU - Geurts, Jeroen J. G.
AU - Reich, Daniel S.
AU - Rocca, Maria A.
AU - Ropele, Stefan
AU - Rovira, Àlex
AU - Sati, Pascal
AU - Toosy, Ahmed T.
AU - Vrenken, Hugo
AU - MAGNIMS Study Group
AU - Gandini Wheeler-Kingshott, Claudia A. M.
AU - Kappos, Ludwig
N1 - Funding Information: C.G. is supported by the Swiss National Science Foundation (SNSF) grant PP00P3-176984, the Stiftung zur F?rderung der gastroenterologischen und allgemeinen klinischen Forschung and the EUROSTAR E! 113682 HORIZON2020. F.B. is supported by the National Institute for Health Research biomedical research center at University College London Hospitals. J.W. is supported by the EU Horizon2020 research and innovation grant (FORCE, 668039). D.S.R. is supported by the Intramural Research Program of National Institute of Neurological Disorders and Stroke, National Institutes of Health. A.T.T. is supported by an Medical Research Council grant (MR/S026088/1). S.R. is supported by the Austrian Science Foundation (FWF) grant I-3001. P.S. is supported by the Intramural Research Program of National Institute of Neurological Disorders and Stroke, National Institutes of Health. H.V. is supported by the Dutch multiple sclerosis Research Foundation, ZonMW and HealthHolland. Publisher Copyright: © 2021 The Author(s). Published by Oxford University Press on behalf of the Guarantors of Brain. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS, which can be compared across CNS regions, patients, and centres. In patients with multiple sclerosis, quantitative MRI techniques such as relaxometry, myelin imaging, magnetization transfer, diffusion MRI, quantitative susceptibility mapping, and perfusion MRI, complement conventional MRI techniques by providing insight into disease mechanisms. These include: (i) presence and extent of diffuse damage in CNS tissue outside lesions (normal-appearing tissue); (ii) heterogeneity of damage and repair in focal lesions; and (iii) specific damage to CNS tissue components. This review summarizes recent technical advances in quantitative MRI, existing pathological validation of quantitative MRI techniques, and emerging applications of quantitative MRI to patients with multiple sclerosis in both research and clinical settings. The current level of clinical maturity of each quantitative MRI technique, especially regarding its integration into clinical routine, is discussed. We aim to provide a better understanding of how quantitative MRI may help clinical practice by improving stratification of patients with multiple sclerosis, and assessment of disease progression, and evaluation of treatment response.
AB - Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS, which can be compared across CNS regions, patients, and centres. In patients with multiple sclerosis, quantitative MRI techniques such as relaxometry, myelin imaging, magnetization transfer, diffusion MRI, quantitative susceptibility mapping, and perfusion MRI, complement conventional MRI techniques by providing insight into disease mechanisms. These include: (i) presence and extent of diffuse damage in CNS tissue outside lesions (normal-appearing tissue); (ii) heterogeneity of damage and repair in focal lesions; and (iii) specific damage to CNS tissue components. This review summarizes recent technical advances in quantitative MRI, existing pathological validation of quantitative MRI techniques, and emerging applications of quantitative MRI to patients with multiple sclerosis in both research and clinical settings. The current level of clinical maturity of each quantitative MRI technique, especially regarding its integration into clinical routine, is discussed. We aim to provide a better understanding of how quantitative MRI may help clinical practice by improving stratification of patients with multiple sclerosis, and assessment of disease progression, and evaluation of treatment response.
KW - imaging
KW - multiple sclerosis
KW - quantitative MRI
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85108997966&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/33970206
UR - http://www.scopus.com/inward/record.url?scp=85108997966&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/brain/awab029
DO - https://doi.org/10.1093/brain/awab029
M3 - Review article
C2 - 33970206
SN - 0006-8950
VL - 144
SP - 1296
EP - 1311
JO - Brain
JF - Brain
IS - 5
ER -