TY - JOUR
T1 - Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe
AU - Mulder, Willem J. M.
AU - Koole, Rolf
AU - Brandwijk, Ricardo J.
AU - Storm, Gert
AU - Chin, Patrick T. K.
AU - Strijkers, Gustav J.
AU - de Mello Donegá, Celso
AU - Nicolay, Klaas
AU - Griffioen, Arjan W.
PY - 2006
Y1 - 2006
N2 - MRI detectable and targeted quantum dots were developed. To that aim, quantum dots were coated with paramagnetic and pegylated lipids, which resulted in a relaxivity, r(1), of nearly 2000 mM(-1)s(-1) per quantum dot. The quantum dots were functionalized by covalently linking alphavbeta3-specific RGD peptides, and the specificity was assessed and confirmed on cultured endothelial cells. The bimodal character, the high relaxivity, and the specificity of this nanoparticulate probe make it an excellent contrast agent for molecular imaging purposes
AB - MRI detectable and targeted quantum dots were developed. To that aim, quantum dots were coated with paramagnetic and pegylated lipids, which resulted in a relaxivity, r(1), of nearly 2000 mM(-1)s(-1) per quantum dot. The quantum dots were functionalized by covalently linking alphavbeta3-specific RGD peptides, and the specificity was assessed and confirmed on cultured endothelial cells. The bimodal character, the high relaxivity, and the specificity of this nanoparticulate probe make it an excellent contrast agent for molecular imaging purposes
U2 - https://doi.org/10.1021/nl051935m
DO - https://doi.org/10.1021/nl051935m
M3 - Article
C2 - 16402777
SN - 1530-6984
VL - 6
SP - 1
EP - 6
JO - Nano letters
JF - Nano letters
IS - 1
ER -