(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

S. Syvanen; G. Luurtsema; C.F.M. Molthoff; A.D. Windhorst; M.C. Huisman; A.A. Lammertsma; R.A. Voskuyl; E.C.M. de Lange

doi:https://doi.org/10.1186/1471-2342-11-1

(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

S. Syvanen, G. Luurtsema, C.F.M. Molthoff, A.D. Windhorst, M.C. Huisman, A.A. Lammertsma, R.A. Voskuyl, E.C.M. de Lange

Radiology and Nuclear Medicine (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

34 Citations (Scopus)

Abstract

Background: Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection of kainate, which leads to development of spontaneous seizures after 3 weeks to 3 months. The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and functionality at an early stage after induction of status epilepticus by kainate.Methods: (R)-[

Original language	English
Article number	1
Journal	BMC medical imaging
Volume	11
DOIs	https://doi.org/10.1186/1471-2342-11-1
Publication status	Published - 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1186/1471-2342-11-1

Cite this

Syvanen, S., Luurtsema, G., Molthoff, C. F. M., Windhorst, A. D., Huisman, M. C., Lammertsma, A. A., Voskuyl, R. A., & de Lange, E. C. M. (2011). (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus. BMC medical imaging, 11, Article 1. https://doi.org/10.1186/1471-2342-11-1

@article{813421cfaf90410cb2b4bde08ceb267e,

title = "(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus",

abstract = "Background: Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection of kainate, which leads to development of spontaneous seizures after 3 weeks to 3 months. The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and functionality at an early stage after induction of status epilepticus by kainate.Methods: (R)-[",

author = "S. Syvanen and G. Luurtsema and C.F.M. Molthoff and A.D. Windhorst and M.C. Huisman and A.A. Lammertsma and R.A. Voskuyl and {de Lange}, E.C.M.",

year = "2011",

doi = "https://doi.org/10.1186/1471-2342-11-1",

language = "English",

volume = "11",

journal = "BMC medical imaging",

issn = "1471-2342",

publisher = "BioMed Central",

}

TY - JOUR

T1 - (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

AU - Syvanen, S.

AU - Luurtsema, G.

AU - Molthoff, C.F.M.

AU - Windhorst, A.D.

AU - Huisman, M.C.

AU - Lammertsma, A.A.

AU - Voskuyl, R.A.

AU - de Lange, E.C.M.

PY - 2011

Y1 - 2011

N2 - Background: Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection of kainate, which leads to development of spontaneous seizures after 3 weeks to 3 months. The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and functionality at an early stage after induction of status epilepticus by kainate.Methods: (R)-[

AB - Background: Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection of kainate, which leads to development of spontaneous seizures after 3 weeks to 3 months. The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and functionality at an early stage after induction of status epilepticus by kainate.Methods: (R)-[

U2 - https://doi.org/10.1186/1471-2342-11-1

DO - https://doi.org/10.1186/1471-2342-11-1

M3 - Article

C2 - 21199574

SN - 1471-2342

VL - 11

JO - BMC medical imaging

JF - BMC medical imaging

M1 - 1

ER -