R-spondin Is More Than Just Wnt's Sidekick

David J. Huels; Owen J. Sansom

doi:https://doi.org/10.1016/j.devcel.2017.05.018

R-spondin Is More Than Just Wnt's Sidekick

David J. Huels, Owen J. Sansom

Center of Experimental and Molecular Medicine (AMC)

Research output: Contribution to journal › Editorial › Academic › peer-review

8 Citations (Scopus)

Abstract

The intestinal crypt and its stem cells are dependent on the Wnt pathway. Reporting in Nature, Yan et al. (2017) show that Wnts and Wnt signaling potentiator R-spondins have non-interchangeable roles. Both are necessary for intestinal stem cell (ISC) maintenance, and R-spondins are the limiting factor that defines ISC number

Original language	English
Pages (from-to)	456-458
Journal	Developmental Cell
Volume	41
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2017.05.018
Publication status	Published - 2017

Access to Document

https://doi.org/10.1016/j.devcel.2017.05.018

Cite this

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title = "R-spondin Is More Than Just Wnt's Sidekick",

abstract = "The intestinal crypt and its stem cells are dependent on the Wnt pathway. Reporting in Nature, Yan et al. (2017) show that Wnts and Wnt signaling potentiator R-spondins have non-interchangeable roles. Both are necessary for intestinal stem cell (ISC) maintenance, and R-spondins are the limiting factor that defines ISC number",

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AB - The intestinal crypt and its stem cells are dependent on the Wnt pathway. Reporting in Nature, Yan et al. (2017) show that Wnts and Wnt signaling potentiator R-spondins have non-interchangeable roles. Both are necessary for intestinal stem cell (ISC) maintenance, and R-spondins are the limiting factor that defines ISC number

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