R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus

R. D. Berkowitz; A. B. van't Wout; N. A. Kootstra; M. E. Moreno; V. D. Linquist-Stepps; C. Bare; C. A. Stoddart; H. Schuitemaker; J. M. McCune

R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus

R. D. Berkowitz, A. B. van't Wout, N. A. Kootstra, M. E. Moreno, V. D. Linquist-Stepps, C. Bare, C. A. Stoddart, H. Schuitemaker, J. M. McCune

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Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

Abstract

Some individuals infected with only R5 strains of human immunodeficiency virus type 1 progress to AIDS as quickly as individuals harboring X4 strains. We determined that three R5 viruses were much less pathogenic than an X4 virus in SCID-hu Thy/Liv mice, suggesting that R5 virus-mediated rapid disease progression is associated with host, not viral, factors

Original language	English
Pages (from-to)	7817-7822
Journal	Journal of Virology
Volume	73
Issue number	9
Publication status	Published - 1999

Cite this

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title = "R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus",

abstract = "Some individuals infected with only R5 strains of human immunodeficiency virus type 1 progress to AIDS as quickly as individuals harboring X4 strains. We determined that three R5 viruses were much less pathogenic than an X4 virus in SCID-hu Thy/Liv mice, suggesting that R5 virus-mediated rapid disease progression is associated with host, not viral, factors",

author = "Berkowitz, {R. D.} and {van't Wout}, {A. B.} and Kootstra, {N. A.} and Moreno, {M. E.} and Linquist-Stepps, {V. D.} and C. Bare and Stoddart, {C. A.} and H. Schuitemaker and McCune, {J. M.}",

year = "1999",

language = "English",

volume = "73",

pages = "7817--7822",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "9",

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TY - JOUR

T1 - R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus

AU - Berkowitz, R. D.

AU - van't Wout, A. B.

AU - Kootstra, N. A.

AU - Moreno, M. E.

AU - Linquist-Stepps, V. D.

AU - Bare, C.

AU - Stoddart, C. A.

AU - Schuitemaker, H.

AU - McCune, J. M.

PY - 1999

Y1 - 1999

N2 - Some individuals infected with only R5 strains of human immunodeficiency virus type 1 progress to AIDS as quickly as individuals harboring X4 strains. We determined that three R5 viruses were much less pathogenic than an X4 virus in SCID-hu Thy/Liv mice, suggesting that R5 virus-mediated rapid disease progression is associated with host, not viral, factors

AB - Some individuals infected with only R5 strains of human immunodeficiency virus type 1 progress to AIDS as quickly as individuals harboring X4 strains. We determined that three R5 viruses were much less pathogenic than an X4 virus in SCID-hu Thy/Liv mice, suggesting that R5 virus-mediated rapid disease progression is associated with host, not viral, factors

M3 - Article

C2 - 10438873

SN - 0022-538X

VL - 73

SP - 7817

EP - 7822

JO - Journal of Virology

JF - Journal of Virology

IS - 9

ER -