TY - JOUR
T1 - Radiofrequency Ablation of the Atherosclerotic Plaque
T2 - a Proof of Concept Study in an Atherosclerotic Model
AU - Ellenbroek, Guilielmus H.J.M.
AU - van Hout, Gerardus P.J.
AU - de Jager, Saskia C.A.
AU - Timmers, Leo
AU - Vink, Aryan
AU - Goldschmeding, Roel
AU - van der Kraak, Petra
AU - Pasterkamp, Gerard
AU - Hoefer, Imo E.
AU - Doevendans, Petrus A.
AU - Appelman, Yolande
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Increased plaque vascularization is causatively associated with the progression of unstable atherosclerotic vessel disease. We investigated the safety and efficacy of heat-generating radiofrequency ablation (RFA) in reducing the number of vessels in the plaque and adventitia and its effect on plaque size and composition. To this end, New Zealand White rabbits were fed a cholesterol-enriched diet and subjected to balloon denudation of the infrarenal aorta to induce atherosclerotic plaque formation. After 13 weeks, the proximal or distal half of the infrarenal aorta was exposed to transluminal RFA. The untreated half served as an intra-individual control. Optical coherence tomography (OCT) was performed directly after RFA. We found that RFA on the rabbit atherosclerotic plaque is safe and leads to decreased intraplaque vessel density and smooth muscle cell content but does not affect other components of plaque composition or size.
AB - Increased plaque vascularization is causatively associated with the progression of unstable atherosclerotic vessel disease. We investigated the safety and efficacy of heat-generating radiofrequency ablation (RFA) in reducing the number of vessels in the plaque and adventitia and its effect on plaque size and composition. To this end, New Zealand White rabbits were fed a cholesterol-enriched diet and subjected to balloon denudation of the infrarenal aorta to induce atherosclerotic plaque formation. After 13 weeks, the proximal or distal half of the infrarenal aorta was exposed to transluminal RFA. The untreated half served as an intra-individual control. Optical coherence tomography (OCT) was performed directly after RFA. We found that RFA on the rabbit atherosclerotic plaque is safe and leads to decreased intraplaque vessel density and smooth muscle cell content but does not affect other components of plaque composition or size.
KW - Atherosclerosis
KW - Neovascularization
KW - Plaque progression
KW - Radiofrequency ablation
KW - Smooth muscle cell
KW - Vasa vasorum
UR - http://www.scopus.com/inward/record.url?scp=85016605634&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s12265-017-9743-3
DO - https://doi.org/10.1007/s12265-017-9743-3
M3 - Article
C2 - 28364193
SN - 1937-5387
VL - 10
SP - 221
EP - 232
JO - Journal of cardiovascular translational research
JF - Journal of cardiovascular translational research
IS - 2
ER -