Randomized controlled trial of the effects of high intensity and low-to-moderate intensity exercise on physical fitness and fatigue in cancer survivors: results of the Resistance and Endurance exercise After ChemoTherapy (REACT) study

C.S. Kampshoff; M.J.M. Chin A Paw; J. Brug; J.W.R. Twisk; G. Schep; M.R. Nijziel; W. van Mechelen; L.M. Buffart

doi:https://doi.org/10.1186/s12916-015-0513-2

Randomized controlled trial of the effects of high intensity and low-to-moderate intensity exercise on physical fitness and fatigue in cancer survivors: results of the Resistance and Endurance exercise After ChemoTherapy (REACT) study

C.S. Kampshoff, M.J.M. Chin A Paw, J. Brug, J.W.R. Twisk, G. Schep, M.R. Nijziel, W. van Mechelen, L.M. Buffart

Research output: Contribution to journal › Article › Academic › peer-review

134 Citations (Scopus)

Abstract

Background: International evidence-based guidelines recommend physical exercise to form part of standard care for all cancer survivors. However, at present, the optimum exercise intensity is unclear. Therefore, we aimed to evaluate the effectiveness of a high intensity (HI) and low-to-moderate intensity (LMI) resistance and endurance exercise program compared with a wait list control (WLC) group on physical fitness and fatigue in a mixed group of cancer survivors who completed primary cancer treatment, including chemotherapy. Methods: Overall, 277 cancer survivors were randomized to 12 weeks of HI exercise (n=91), LMI exercise (n=95), or WLC (n=91). Both interventions were identical with respect to exercise type, duration and frequency, and only differed in intensity. Measurements were performed at baseline (4-6 weeks after primary treatment) and post-intervention. The primary outcomes were cardiorespiratory fitness (peakVO

Original language	English
Article number	275
Journal	BMC medicine
Volume	13
DOIs	https://doi.org/10.1186/s12916-015-0513-2
Publication status	Published - 2015

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Cite this

Kampshoff, C. S., Chin A Paw, M. J. M., Brug, J., Twisk, J. W. R., Schep, G., Nijziel, M. R., van Mechelen, W., & Buffart, L. M. (2015). Randomized controlled trial of the effects of high intensity and low-to-moderate intensity exercise on physical fitness and fatigue in cancer survivors: results of the Resistance and Endurance exercise After ChemoTherapy (REACT) study. BMC medicine, 13, Article 275. https://doi.org/10.1186/s12916-015-0513-2

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abstract = "Background: International evidence-based guidelines recommend physical exercise to form part of standard care for all cancer survivors. However, at present, the optimum exercise intensity is unclear. Therefore, we aimed to evaluate the effectiveness of a high intensity (HI) and low-to-moderate intensity (LMI) resistance and endurance exercise program compared with a wait list control (WLC) group on physical fitness and fatigue in a mixed group of cancer survivors who completed primary cancer treatment, including chemotherapy. Methods: Overall, 277 cancer survivors were randomized to 12 weeks of HI exercise (n=91), LMI exercise (n=95), or WLC (n=91). Both interventions were identical with respect to exercise type, duration and frequency, and only differed in intensity. Measurements were performed at baseline (4-6 weeks after primary treatment) and post-intervention. The primary outcomes were cardiorespiratory fitness (peakVO",

author = "C.S. Kampshoff and {Chin A Paw}, M.J.M. and J. Brug and J.W.R. Twisk and G. Schep and M.R. Nijziel and {van Mechelen}, W. and L.M. Buffart",

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Kampshoff, CS, Chin A Paw, MJM, Brug, J, Twisk, JWR, Schep, G, Nijziel, MR, van Mechelen, W & Buffart, LM 2015, 'Randomized controlled trial of the effects of high intensity and low-to-moderate intensity exercise on physical fitness and fatigue in cancer survivors: results of the Resistance and Endurance exercise After ChemoTherapy (REACT) study', BMC medicine, vol. 13, 275. https://doi.org/10.1186/s12916-015-0513-2

Randomized controlled trial of the effects of high intensity and low-to-moderate intensity exercise on physical fitness and fatigue in cancer survivors: results of the Resistance and Endurance exercise After ChemoTherapy (REACT) study. / Kampshoff, C.S.; Chin A Paw, M.J.M.; Brug, J. et al.
In: BMC medicine, Vol. 13, 275, 2015.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Randomized controlled trial of the effects of high intensity and low-to-moderate intensity exercise on physical fitness and fatigue in cancer survivors: results of the Resistance and Endurance exercise After ChemoTherapy (REACT) study

AU - Kampshoff, C.S.

AU - Chin A Paw, M.J.M.

AU - Brug, J.

AU - Twisk, J.W.R.

AU - Schep, G.

AU - Nijziel, M.R.

AU - van Mechelen, W.

AU - Buffart, L.M.

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Kampshoff CS, Chin A Paw MJM, Brug J, Twisk JWR, Schep G, Nijziel MR et al. Randomized controlled trial of the effects of high intensity and low-to-moderate intensity exercise on physical fitness and fatigue in cancer survivors: results of the Resistance and Endurance exercise After ChemoTherapy (REACT) study. BMC medicine. 2015;13:275. doi: https://doi.org/10.1186/s12916-015-0513-2