TY - JOUR
T1 - Rapid reinfection with SARS-CoV-2 variant-of-concern Alpha detected in a nurse during an outbreak at a non-covid inpatient ward
T2 - lessons learned
AU - Koopsen, Jelle
AU - Dekker, Mireille
AU - Thung, Philip
AU - Jonges, Marcel
AU - Vennema, Harry
AU - Leenstra, Tjalling
AU - Eggink, Dirk
AU - Welkers, Matthijs R. A.
AU - Struijs, Peter A. A.
AU - Reusken, Chantal
AU - van Mansfeld, Rosa
AU - de Jong, Menno D.
AU - Schinkel, Janke
AU - Spijkerman, Ingrid J. B.
N1 - Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - We describe the lessons learned during a SARS-CoV-2 variant-of-concern Alpha outbreak investigation at a normal care unit in a university hospital in Amsterdam in December 2020. The outbreak consisted of nine nurses and two roomed-in patient family members. (attack rate 18%). One nurse tested positive with a phylogenetically distinct variant, after a documented infection 83 days prior. Three key points were taken from this investigation. First, it was controlled by adherence to existing guidelines, despite increased transmissibility of the variant. Second, viral sequencing can inform transmission cluster inference, but the epidemiological context is essential to draw appropriate conclusions. Third, reinfections with Alpha variants can occur rapidly after primary infection.
AB - We describe the lessons learned during a SARS-CoV-2 variant-of-concern Alpha outbreak investigation at a normal care unit in a university hospital in Amsterdam in December 2020. The outbreak consisted of nine nurses and two roomed-in patient family members. (attack rate 18%). One nurse tested positive with a phylogenetically distinct variant, after a documented infection 83 days prior. Three key points were taken from this investigation. First, it was controlled by adherence to existing guidelines, despite increased transmissibility of the variant. Second, viral sequencing can inform transmission cluster inference, but the epidemiological context is essential to draw appropriate conclusions. Third, reinfections with Alpha variants can occur rapidly after primary infection.
KW - Infection control guidelines
KW - Infection prevention and control
KW - Nosocomial transmission
KW - Outbreak investigation
UR - http://www.scopus.com/inward/record.url?scp=85115700394&partnerID=8YFLogxK
U2 - https://doi.org/10.1186/s13756-021-01008-4
DO - https://doi.org/10.1186/s13756-021-01008-4
M3 - Article
C2 - 34565476
SN - 2047-2994
VL - 10
JO - Antimicrobial resistance and infection control
JF - Antimicrobial resistance and infection control
IS - 1
M1 - 137
ER -