Ratiology and a Complementary Class of Metrics for Cardiovascular Investigations

Peter L. M. Kerkhof, Richard A. Peace, Neal Handly

Research output: Contribution to journalReview articleAcademicpeer-review

32 Citations (Scopus)


Cardiovascular investigations often involve ratio-based metrics or differences: ejection fraction, arterial pressure augmentation index, coronary fractional flow reserve, pulse pressure. Focusing on a single number (ratio or difference) implies that information is lost. The lost companions constitute a well-defined but thus far unrecognized class, having additive value, a physical dimension, and often a physiological meaning. Physiologists should play a prominent role in exploring these complementary avenues and also define alternatives.
Original languageEnglish
Pages (from-to)250-263
Number of pages14
Issue number4
Publication statusPublished - 1 Jul 2019


  • Biomarkers
  • Ejection fraction
  • Statistics
  • fractional flow reserve
  • ratio analysis

Cite this